dc.creator | Tavares Vázquez, Eva | es |
dc.creator | Maldonado Ordóñez, Rosario | es |
dc.creator | Ojeda Murillo, María Luisa | es |
dc.creator | Miñano Sánchez, Javier | es |
dc.date.accessioned | 2016-09-27T11:24:32Z | |
dc.date.available | 2016-09-27T11:24:32Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Tavares Vázquez, E., Maldonado Ordóñez, R., Ojeda Murillo, M.L. y Miñano Sánchez, J. (2005). Circulating inflammatory mediators during start of fever in differential diagnosis of gram-negative and gram-positive infections in leukopenic rats. Clinical and Diagnostic Laboratory Immunology, 12 (9), 1085-1093. | |
dc.identifier.issn | 1071-412X | es |
dc.identifier.uri | http://hdl.handle.net/11441/45793 | |
dc.description.abstract | Gram-negative and gram-positive infections have been considered the most important causes of morbidity
and mortality in patients with leukopenia following chemotherapy. However, discrimination between bacterial
infections and harmless fever episodes is difficult. Because classical inflammatory signs of infection are often
absent and fever is frequently the only sign of infection, the aim of this study was to assess the significance of
serum interleukin-6 (IL-6), IL-10, macrophage inflammatory protein-2 (MIP-2), procalcitonin (PCT), and
C-reactive protein (CRP) patterns in identifying bacterial infections during start of fever in normal and
cyclophosphamide-treated (leukopenic) rats following an injection of lipopolysaccharide (LPS) or muramyl
dipeptide (MDP) as a model for gram-negative and gram-positive bacterial infections. We found that, com-
pared to normal rats, immunosuppressed animals exhibited significantly higher fevers and lesser production
of all mediators, except IL-6, after toxin challenge. Moreover, compared to rats that received MDP, both groups
of animals that received an equivalent dose of LPS showed significantly higher fevers and greater increase in
serum cytokine levels. Furthermore, in contrast to those in immunocompetent rats, serum levels of IL-6 and
MIP-2 were not significantly changed in leukopenic animals after MDP injection. Other serum markers such
as PCT and CRP failed to discriminate between bacterial stimuli in both groups of animals. These results
suggest that the use of the analyzed serum markers at an early stage of fever could give useful information for
the clinician for excluding gram-negative from gram-positive infections | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | American Society for Microbiology | es |
dc.relation.ispartof | Clinical and Diagnostic Laboratory Immunology, 12 (9), 1085-1093. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Circulating inflammatory mediators during start of fever in differential diagnosis of gram-negative and gram-positive infections in leukopenic rats | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.relation.publisherversion | https://dx.doi.org/10.1128/CDLI.12.9.1085-1093.2005 | es |
dc.identifier.doi | 10.1128/CDLI.12.9.1085-1093.2005 | es |
idus.format.extent | 9 p. | es |
dc.journaltitle | Clinical and Diagnostic Laboratory Immunology | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 9 | es |
dc.publication.initialPage | 1085 | es |
dc.publication.endPage | 1093 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/45793 | |