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The yeast p24 complex regulates gpi-anchored protein Transport and quality control by monitoring anchor remodeling
dc.creator | Castillon, Guillaume Alain | es |
dc.creator | Aguilera Romero, María Auxiliadora | es |
dc.creator | Manzano López, Javier | es |
dc.creator | Epsteina, Sharon | es |
dc.creator | Kajiwarac, Kentaro | es |
dc.creator | Funato, Kouichi | es |
dc.creator | Watanabe, Reika | |
dc.creator | Riezman, Howard | |
dc.creator | Muñiz Guinea, Manuel | |
dc.date.accessioned | 2016-04-19T13:19:24Z | |
dc.date.available | 2016-04-19T13:19:24Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1939-4586 | es |
dc.identifier.uri | http://hdl.handle.net/11441/40101 | |
dc.description.abstract | Glycosylphosphatidylinositol (GPI)-anchored proteins are secretory proteins that are attached to the cell surface of eukaryotic cells by a glycolipid moiety. Once GPI anchoring has occurred in the lumen of the endoplasmic reticulum (ER), the structure of the lipid part on the GPI anchor undergoes a remodeling process prior to ER exit. In this study, we provide evidence suggesting that the yeast p24 complex, through binding specifically to GPI- anchored proteins in an anchor-dependent manner, plays a dual role in their selective traffick - ing. First, the p24 complex promotes efficient ER exit of remodeled GPI-anchored proteins after concentration by connecting them with the COPII coat and thus facilitates their incorpo - ration into vesicles. Second, it retrieves escaped, unremodeled GPI-anchored proteins from the Golgi to the ER in COPI vesicles. Therefore the p24 complex, by sensing the status of the GPI anchor, regulates GPI-anchored protein intracellular transport and coordinates this with correct anchor remodeling | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | American Society for Cell Biology | es |
dc.relation.ispartof | Molecular Biology of the Cell, 22 (16), 2924-2936 | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | The yeast p24 complex regulates gpi-anchored protein Transport and quality control by monitoring anchor remodeling | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.relation.publisherversion | http://0-www.molbiolcell.org.fama.us.es/content/22/16/2924 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1091/mbc.E11-04-0294 | |
dc.identifier.doi | 10.1091/mbc.E11-04-0294 | |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/40101 |
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