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Funcionalidad del aceite de oliva virgen extra en la artritis reumatoide experimental

Opened Access Funcionalidad del aceite de oliva virgen extra en la artritis reumatoide experimental
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Autor: Rosillo Ramírez, María de los Ángeles
Director: Alarcón de la Lastra Romero, Catalina
Sánchez Hidalgo, Marina
Departamento: Universidad de Sevilla. Departamento de Farmacología
Fecha: 2016-02-23
Tipo de documento: Tesis Doctoral
Resumen: Introduction Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by inflammation of the synovial membrane and progressive destruction of the articular cartilage and bone. (Salgado and Maneiro 2014). RA patients exhibit an inflammatory chronic condition, which usually affects symmetrically arthrodial and small joints of hands and feet Global prevalence of RA has been estimated to be around 0.5-1.0% of adults in developed countries with a large variation across regions and approximately three-times more common in the female gender. The disease may begin at any age, but around 80% of all patients initiate the disease between the ages of 35 and 50 years (Rudan et al. 2015). Although the specific triggers and exact mechanisms of tissue damage in RA is still unknown, an increase in inflammatory mediators as well as a dysregulation of the immune system with uncontrolled T cell activity, play a remarkable role in its pathogenesis. Pharmacological treatment in A...
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Tamaño: 4.529Mb
Formato: PDF

URI: http://hdl.handle.net/11441/39087

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