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Lipid Composition and Fluidity in the Jejunal Brush-Border Membrane of Spontaneously Hypertensive Rats. Effects on Activities of Membrane- Bound Proteins

 

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dc.creator Vázquez Cueto, Carmen María
dc.creator Zanetti, Rosana
dc.creator Ruiz Gutiérrez, Valentina
dc.date.accessioned 2016-02-22T11:38:36Z
dc.date.available 2016-02-22T11:38:36Z
dc.date.issued 1996
dc.identifier.issn 0144-8463 es
dc.identifier.uri http://hdl.handle.net/11441/36239
dc.description.abstract The lipid compositíon and fluidity of jejunal brush-border membrane vesicles (BBMV) have been studied in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats. The activities of both Na+-dependent D-glucose cotransport and Na+-H antiport have also been determined. A significan! increase in the level of free cholesterol was observed in jejunal BBMV from SHR compared to WKY rats. Since phospholipid values did not change in either group of animals, a significan! enhancement in the free cholesterol/phospholipid ratio was observed in SHR. A decrease in the levels of phosphatidylethanolamine together with an increase in the values of phos­ phatidylserine was observed in hypertensive rats. Although the content of phosphatidylcholine (PC) and sphingomyelin (SM) was not singificantly altered in SHR, the ratio PC/SM significantly increased in these animals when compared to WKY rats. The majar fatty acids present in bursh-border membranes prepared from SHR and WKY rats were palmitic (16:0), stearic (18:0), oleic (18:1, n-9) and linoleic (18:2, n-6), and the fatty acid composition was not modified by the hypertension. A decreased fluorescence polarization, i.e., increased membrane ftuidity, was observed in SHR, which was not correlated to the increased ratio of cholesterol/phospholipid found in the brush-border membrane isolated from these animals. These structural changes found in SHR were associated to an enhancement in both Na+ -dependent D-glucose transport and Na+-H+ antiport activíty in the jejunal BBMVof SHR. es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Portland Press Ltd es
dc.relation.ispartof Bioscience Reports, 16, 217-226 es
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.subject Spontaneously hypertensive rat es
dc.subject Brush-border membrane es
dc.subject Lipid ftuídity es
dc.subject Lípíd composi­tion es
dc.subject D-glucose es
dc.subject Na+ -H+ exchanger es
dc.title Lipid Composition and Fluidity in the Jejunal Brush-Border Membrane of Spontaneously Hypertensive Rats. Effects on Activities of Membrane- Bound Proteins es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Fisiología es
dc.relation.publisherversion 10.1007/BF01207336 es
dc.identifier.doi http://dx.doi.org/10.1007/BF01207336 es
dc.identifier.idus https://idus.us.es/xmlui/handle/11441/36239
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