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Comparative evaluation of the metabolic effects of hydroxytyrosol and its lipophilic derivatives (hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether) in hypercholesterolemic rats

Opened Access Comparative evaluation of the metabolic effects of hydroxytyrosol and its lipophilic derivatives (hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether) in hypercholesterolemic rats

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Autor: Espartero Sánchez, José Luis
Tabernero, Marta
Sarriá, Beatriz
Largo, Carlota
Martínez López, Sara
Madrona, Andrés
Bravo, Laura
Mateos, Raquel
Departamento: Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica
Fecha: 2014
Publicado en: Food and Function, 5, 1556-1563
Tipo de documento: Artículo
Resumen: Hydroxytyrosol (HT), a virgin olive oil phenolic phytochemical with proven health benefits, has been used to generate new lipophilic antioxidants to preserve fats and oils against autoxidation. The aim of this work is to comparatively evaluate the physiological effects of HT and its lipophilic derivatives, hydroxytyrosyl acetate (HT-Ac) and ethyl hydroxytyrosyl ether (HT-Et), in high-cholesterol fed animals. Male Wistar rats (n ¼ 8) were fed a standard diet (C group), a cholesterol-rich diet (Chol group) or a cholesterol-rich diet supplemented with phenolic compounds (HT group, HT-Ac group and HT-Et group) for 8 weeks. Body and tissue weights, the lipid profile, redox status, and biochemical, hormonal, and inflammatory biomarkers were evaluated. Plasma levels of total cholesterol, LDL cholesterol, glucose, insulin and leptin, as well as malondialdehyde in serum increased in Chol compared to C (p < 0.05). Rats fed the test diets had improved glucose, insulin, leptin and MD...
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Tamaño: 296.7Kb
Formato: PDF

URI: http://hdl.handle.net/11441/34936

DOI: http://dx.doi.org/10.1039/C3FO60677E

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