Show simple item record

Article

dc.creatorEspartero Sánchez, José Luis
dc.creatorTabernero, Marta
dc.creatorSarriá, Beatriz
dc.creatorLargo, Carlota
dc.creatorMartínez López, Sara
dc.creatorMadrona, Andrés
dc.creatorBravo, Laura
dc.creatorMateos, Raquel
dc.date.accessioned2016-02-17T08:31:33Z
dc.date.available2016-02-17T08:31:33Z
dc.date.issued2014
dc.identifier.citationEspartero Sánchez, J.L., Tabernero, M., Sarriá, B., Largo, C., Martínez López, S., Madrona, A.,...,Mateos, R. (2014). Comparative evaluation of the metabolic effects of hydroxytyrosol and its lipophilic derivatives (hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether) in hypercholesterolemic rats. Food and Function, 5, 1556-1563.
dc.identifier.issn2042-6496es
dc.identifier.urihttp://hdl.handle.net/11441/34936
dc.description.abstractHydroxytyrosol (HT), a virgin olive oil phenolic phytochemical with proven health benefits, has been used to generate new lipophilic antioxidants to preserve fats and oils against autoxidation. The aim of this work is to comparatively evaluate the physiological effects of HT and its lipophilic derivatives, hydroxytyrosyl acetate (HT-Ac) and ethyl hydroxytyrosyl ether (HT-Et), in high-cholesterol fed animals. Male Wistar rats (n ¼ 8) were fed a standard diet (C group), a cholesterol-rich diet (Chol group) or a cholesterol-rich diet supplemented with phenolic compounds (HT group, HT-Ac group and HT-Et group) for 8 weeks. Body and tissue weights, the lipid profile, redox status, and biochemical, hormonal, and inflammatory biomarkers were evaluated. Plasma levels of total cholesterol, LDL cholesterol, glucose, insulin and leptin, as well as malondialdehyde in serum increased in Chol compared to C (p < 0.05). Rats fed the test diets had improved glucose, insulin, leptin and MDA levels and antioxidant capacity status, with HT-Ac being the most effective compound. The studied phenolic compounds also modulated TNF-a and IL-1b plasma levels compared to Chol. HT-Ac and HT-Et improved adipose tissue distribution and adipokine production, decreasing MCP-1 and IL-1b levels. Our results confirm the metabolic effects of HT, which are maintained and even improved by hydrophobic derivatives, particularly HT-Ac.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherRoyal Society of Chemistryes
dc.relation.ispartofFood and Function, 5, 1556-1563.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAgentses
dc.subjectCholesteroles
dc.subjectEtherses
dc.subjectGlucosees
dc.subjectInsulines
dc.subjectMetabolismes
dc.subjectNutritiones
dc.subjectPhenolses
dc.subjectRatses
dc.subjectVolatile fatty acidses
dc.subjectAntioxidant capacityes
dc.subjectComparative evaluationses
dc.subjectHydrophobic derivativeses
dc.subjectLipophilic antioxidantses
dc.subjectPhenolic compoundses
dc.subjectPhenolic phytochemicales
dc.subjectPhysiological effectses
dc.subjectTotal cholesterolses
dc.titleComparative evaluation of the metabolic effects of hydroxytyrosol and its lipophilic derivatives (hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether) in hypercholesterolemic ratses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/submittedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química Orgánica y Farmacéuticaes
dc.relation.publisherversion10.1039/C3FO60677Ees
dc.relation.publisherversionhttp://dx.doi.org/10.1039/C3FO60677Ees
dc.identifier.doi10.1039/C3FO60677Ees
dc.journaltitleFood and Functiones
dc.publication.volumen5es
dc.publication.initialPage1556es
dc.publication.endPage1563es
dc.identifier.idushttps://idus.us.es/xmlui/handle/11441/34936

FilesSizeFormatViewDescription
preprint_comparative evaluation ...440.1KbIcon   [PDF] View/Open  

This item appears in the following collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional