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Artículo
Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors
(Springer Verlag, 2011)
The paired box transcription factor Pax8 is critical for development of the eye, thyroid gland as well as the urinary and reproductive organs. In adult, Pax8 overexpression is associated with kidney, ovarian and thyroid ...
Artículo
TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage
(American Society for Biochemistry and Molecular Biology, 2011)
Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand break via a 5′-phosphotyrosyl bond. Although these intermediates are normally transient, they ...
Artículo
PS Integrins and Laminins: Key Regulators of Cell Migration during Drosophila Embryogenesis
(Public Library of Science, 2011)
During embryonic development, there are numerous cases where organ or tissue formation depends upon the migration of primordial cells. In the Drosophila embryo, the visceral mesoderm (vm) acts as a substrate for the migration ...
Artículo
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
(2011)
One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts ...
Artículo
The Rad50 coiled-coil domain is indispensable for Mre11 complex functions
(Nature Publishing Group, 2011)
The Mre11 complex (Mre11, Rad50 and Xrs2 in Saccharomyces cerevisiae) influences diverse functions in the DNA damage response. The complex comprises the globular DNA-binding domain and the Rad50 hook domain, which are ...
Artículo
Zim17/Tim15 links mitochondrial iron–sulfur cluster biosynthesis to nuclear genome stability
(Oxford University Press, 2011)
Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron–sulfur cluster biosynthesis is important for the maintenance of nuclear genome stability in Saccharomyces cerevisiae. ...
Artículo
Artículo
The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores
(Elsevier, 2011)
Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. Examining checkpoint-dependent mechanisms controlling fork stability, we find that fork reversal and ...
Artículo
Application of flow focusing to the break-up of a magnetite suspension jet for the production of paramagnetic microparticles
(2011)
Paramagnetic particles offer an extensive improvement in the magnetic separation or purification of a wide variety of protein molecules. Most commercial paramagnetic particles are synthesized by laborious and costly ...