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Artículo
Protection and repair of the nigrostriatal pathway with stem-cell-derived carotid body glomus cell transplants in chronic MPTP Parkinsonian model
(MDPI, 2023-03-14)
Antiparkinsonian carotid body (CB) cell therapy has been proven to be effective in rodent and nonhuman primate models of Parkinson’s disease (PD), exerting trophic protection and restoration of the dopaminergic nigrostriatal ...
Artículo
Artículo
Rat Adrenal Chromaffin Cells Are Neonatal CO2 Sensors
(2005)
We studied the participation of adrenal medulla (AM) chromaffin cells in hypercapnic chemotransduction. Using amperometric recordings, we measured catecholamine (CAT) secretion from cells inAMslices of neonatal and adult ...
Artículo
Combined effects of aquaporin-4 and hypoxia produce age-related hydrocephalus
(Elsevier, 2018)
Aquaporin-4, present in ependymal cells, in glia limiting and abundantly in pericapillary astrocyte foot pro cesses, and aquaporin-1, expressed in choroid plexus epithelial cells, play an important role in cerebrospinal fluid ...
Artículo
Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons
(1990)
The interaction of thyrotropin-releasing hormone (TRH) and its physiological metabolite TRH-OH with Na+ channels was studied in enzymatically dissociated guinea pig septal neurons by using the whole-cell variant of the ...
Artículo
Is Carotid Body Infection Responsible for Silent Hypoxemia in COVID-19 Patients?
(Oxford University Press (OUP), 2021)
Tesis Doctoral
Xenotrasplantes de cuerpo carotideo en ratones parkinsonianos inmunodeprimidos.
(2017-09-26)
Los trasplantes intraestriatales de cuerpo carotídeo (CC) han mostrado un claro efecto beneficioso en modelos animales de parkinsonismo, ejerciendo una acción trófica, mediada por la liberación del factor neurotrófico ...
Artículo
Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate
(Nature Publishing Group, 2023)
Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective efficacy against infection in the brain is yet unclear. Here, in the susceptible transgenic K18-hACE2 mouse model of severe coronavirus ...
Artículo
Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration
(Springer Nature, 2021)
A deeper understanding of early disease mechanisms occurring in Parkinson’s disease (PD) is needed to reveal restorative targets. Here we report that human induced pluripotent stem cell (iPSC)-derived dopaminergic neurons ...
Tesis Doctoral
GDNF y cuerpo carotídeo: implicaciones funcionales y uso en terapia celular
(2007-04-19)
El proyecto que se desarrolla en esta Tesis Doctoral se ha centrado en el estudio de los mecanismos celulares y moleculares por los que el trasplante de cuerpo carotídeo (CC) produce recuperación en modelos experimentales ...