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Mostrando ítems 1-8 de 8
Artículo
Influence of high glucose and advanced glycation end-products (ages) levels in human osteoblast-like cells gene expression
(2016)
Background: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporotic fracture. Several factors have been identified as being potentially responsible for this risk, such as alterations in bone ...
Artículo
Spanish National Registry of Major Osteoporotic Fractures (REFRA) seen at Fracture Liaison Services (FLS): objectives and quality standards
(SPRINGER, 2022)
Summary REFRA-FLS is a new registry in Spain aimed at identifying individuals over 50 years of age with a fragility fracture. Using this registry, we found hip fracture is the most prevalent fracture. Treatment for ...
Artículo
Microstructural and strength changes in trabecular bone in elderly patients with type 2 diabetes mellitus
(MPDI, 2021-03-23)
Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases worldwide and it is associated with an increased risk of osteoporosis and fragility fractures. Our aim is to analyze the effect of T2DM on bone ...
Artículo
Estudio génico (OPG, RANKL, Runx2 y receptores AGE) en cultivos de osteoblastos humanos de pacientes con diabetes mellitus tipo 2 y fractura de cadera. Influencia de los niveles de glucosa y AGEs
(Sociedad Española de Investigación Ósea y del Metabolismo Mineral, 2012)
Introducción: La diabetes mellitus (DM) tipo 2 se asocia a un mayor riesgo de fractura osteoporótica. Se han señalado múltiples factores como posibles mecanismos responsables, entre ellos las alteraciones en el remodelado ...
Artículo
¿Qué son los microARNs? Posibles biomarcadores y dianas terapéuticas en la enfermedad osteoporótica
(Sociedad Espanola de Investigacion Osea y del Metabolismo Mineral (SEIOMM), 2016)
Los micro-ARN (miRs) son pequeñas moléculas de ARN no codificantes que regulan la expresión génica a nivel post-transcripcional. Generalmente actúan sobre la expresión genética mediante el silenciamiento o degradación de ...
Artículo
Fragility fractures and imminent fracture risk in the spanish population: a retrospective observational cohort study
(MDPI, 2021-03-05)
Fragility fractures constitute a major public health problem worldwide, causing important high morbidity and mortality rates. The aim was to present the epidemiology of fragility fractures and to assess the imminent risk ...
Artículo
Circulating Osteogenic Progenitor Cells Enhanced with Teriparatide or Denosumab Treatment
(MDPI, 2022)
Circulating osteogenic precursor (COP) cells are peripheral blood cells with a capacity for osteogenesis. The objective of our study was to ascertain the percentage of COPs as an early biomarker of osteoporosis and the ...
Artículo
Modifying RANKL/OPG mRNA expression in differentiating and growing human primary osteoblasts
(Georg Thieme, 2008-12-01)
The OPG / RANKL system in primary cultures of human osteoblasts has been studied by di ff erent authors. However, very few studies have been performed on gene expression of RANKL and OPG at di ff erent stages of ...