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Mostrando ítems 51-60 de 107
Artículo
Insecticide Reproductive Toxicity Profile: Organophosphate, Carbamate and Pyrethroids
(Avens Publishing Group, 2017)
Exposure to pesticides is very common world-wide, and is broadly known the acute toxic effects to humans of pesticides following a high dose exposure; however, knowledge about chronic low-dose adverse effects to specific ...
Artículo
Brainiac Caspases: Beyond the Wall of Apoptosis
(Frontiers Media, 2019)
For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions. In this mini review, ...
Artículo
Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation
(Frontiers Media, 2018)
Microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, including Alzheimer’s disease (AD). The use of primary microglial cell cultures has proved to be a ...
Artículo
Synthesis and Antioxidant Activity of Alkyl Nitroderivatives of Hydroxytyrosol
(MDPI AG, 2016)
A series of alkyl nitrohydroxytyrosyl ether derivatives has been synthesized from free hydroxytyrosol (HT), the natural olive oil phenol, in order to increase the assortment of compounds with potential neuroprotective ...
Artículo
Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform
(Future Science Group, 2019)
Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable disease models, has precluded the development of effective therapies ...
Artículo
Glutaredoxins are essential for stress adaptation in the cyanobacterium Synechocystis sp. PCC 6803
(Frontiers media, 2013)
Glutaredoxins are small redox proteins able to reduce disulfides and mixed disulfides between GSH and proteins. Synechocystis sp. PCC 6803 contains three genes coding for glutaredoxins: ssr2061 (grxA) and slr1562 (grxB) ...
Artículo
Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration
(Nature, 2017)
Traumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in Western society, with an estimate of 2.5 million people affected per year in Europe, indicating the need for advances in TBI ...
Artículo
Microglial subtypes: diversity within the microglial community
(EMBO Press, 2019)
Microglia are brain-resident macrophages forming the first active immune barrier in the central nervous system. They fulfill multiple functions across development and adulthood and under disease conditions. Current ...
Artículo
NADPH-thioredoxin reductase c mediates the response to oxidative stress and thermotolerance in the cyanobacterium anabaena sp. pcc7120
(Frontiers Media S.A., 2016)
NADPH-thioredoxin reductase C (NTRC) is a bimodular enzyme composed of an NADPH-thioredoxin reductase and a thiioredoxin domain extension in the same protein. In plants, NTRC has been described to be involved in the ...
Artículo
How the Local Geometry of the Cu-Binding Site Determines the Thermal Stability of Blue Copper Proteins
(Elsevier, 2011-01)
Identifying the factors that govern the thermal resistance of cupredoxins is essential for understanding their folding and stability, and for improving our ability to design highly stable enzymes with potential biotechnological ...