Now showing items 1-2 of 2
Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism [Article]
(BioMed Central, 2015)
Background We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and associated neurotoxicity. Importantly, a profuse non-nuclear activation of cleaved caspases 8 and 3 was ...
TET2 Regulates the Neuroinflammatory Response in Microglia [Article]
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known about their epigenomic ...