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Artículo
Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition
(Wiley-Blackwell, 2009)
Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression of several age-related neurodegenerative disorders. However, the mechanisms linking proteasome ...
Artículo
Proteostasis Dysfunction in Aged Mammalian Cells. The Stressful Role of Inflammation
(Frontiers Media S.A., 2021)
Aging is a biological and multifactorial process characterized by a progressive and irreversible deterioration of the physiological functions leading to a progressive increase in morbidity. In the next decades, the world ...
Artículo
Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability
(Wiley-Blackwell, 2020)
Diabetes and metabolic syndrome are associated with the typical American high glycemia diet and result in accumulation of high levels of advanced glycation end products (AGEs), particularly upon aging. AGEs form when sugars ...