Listar Artículos (Bioquímica y Biología Molecular) por título
Mostrando ítems 8-27 de 219
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Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse
(SOC NEUROSCIENCE, 2011-02-09)Synchronous neurotransmitter releaseis a highly regulated processthattakes place at specializations atthe presynapticmembrane ...
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Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo
(Public Library of Science, 2017)Background Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number ...
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Advantages and Disadvantages of Apoptosis in the Aging Process
(Wiley-Blackwell, 2019)Researchers cannot predict as yet how long a human being can live. Life expectancy has been steadily increasing in the ...
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Adverse health effects in women farmers indirectly exposed to pesticides
(MDPI, 2021-05-31)Farmers are among the most vulnerable populations because of the exposure to low levels of pesticides. Acetylcholinesterase ...
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Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model
(American Society for Biochemistry and Molecular Biology Inc., 2011)Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, ...
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Aging and Oxidative Stress Decrease Pineal Elongation Factor 2: In Vivo Protective Effect of Melatonin in Young Rats Treated With Cumene Hydroperoxide
(Wiley-Blackwell, 2017)We studied the alterations of Elongation Factor 2 (eEF2) in the pineal gland of aged rats as well as the possible protective ...
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AICAR Stimulates the Pluripotency Transcriptional Complex in Embryonic Stem Cells Mediated by PI3K, GSK3β, and β-Catenin
(American Chemical Society, 2020)Pluripotent stem cells maintain the property of self-renewal and differentiate into all cell types under clear environments. ...
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Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice
(SOC NEUROSCIENCE, 2010)Low levels of survival motor neuron (SMN) protein result in spinal muscular atrophy (SMA), a severe genetic disease ...
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Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease
(Wiley, 2020)Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques ...
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Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death
(Nature Publishing Group, 2015)The brains of patients with Alzheimer's disease (AD) present elevated levels of tumor necrosis factor-α (TNFα), a cytokine ...
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Analysis of ceftriaxone and ceftazidime distribution in cerebrospinal fluid of and cerebral extracellular space in awake rats by in vivo microdialysis
(American Society for Microbiology, 1995)In vivo microdialysis was used to estimate the extracellular concentrations of ceftazidime and ceftriaxone, two expanded-spectrum ...
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Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells
(Frontiers Media, 2023)The subventricular zone (SVZ) is a brain region that contains neural stem cells and progenitor cells (NSCs/NPCs) from ...
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APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
(Springer Nature, 2022)ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and ...
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Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients
(Elsevier, 2011-01)We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced ...
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Application of a Protein Hydrolysate-Based Biostimulant Obtained from Slaughterhouse Sludge on Pepper Crops
(MDPI, 2023-10-01)Currently, biostimulants obtained from protein hydrolysates are considered essential agronomic tools to promote sustainable ...
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ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain
(Nature Research, 2023)Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized ...
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Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors
(American Society for Clinical Investigation, 2022)New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the ...
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Assessment of the oxidative status in mother-child couples from Seville (Spain): A prospective cohort study
(Elsevier, 2023-10)Pregnancy requires a high demand of energy, which leads to an increase of oxidative stress. The aim of this study was to ...
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Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability
(Wiley-Blackwell, 2020)Diabetes and metabolic syndrome are associated with the typical American high glycemia diet and result in accumulation of ...
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Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease
(BMC, 2022)Alzheimer’s disease (AD) is a major adult-onset neurodegenerative condition with no available treatment. Compelling reports ...