Listar Artículos (Bioquímica y Biología Molecular) por título
Mostrando ítems 83-102 de 223
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GABAa and a-Amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus
(American Society for Biochemistry and Molecular Biology, 2000)We have investigated the age-dependent modifications in the expression of eight different subunits of the γ-aminobutyric ...
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Gal3 Plays a Deleterious Role in a Mouse Model of Endotoxemia
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Lipopolysaccharide (LPS)-induced endotoxemia induces an acute systemic inflammatory response that mimics some important ...
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Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon
(Frontiers Media, 2021)Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the ...
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Galectin-3 depletion tames pro-tumoural microglia and restrains cancer cells growth
(Elsevier, 2024-04-16)Galectin-3 (Gal-3) is a multifunctional protein that plays a pivotal role in the initiation and progression of various ...
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Galectin-3 is elevated in CSF and is associated with A beta deposits and tau aggregates in brain tissue in Alzheimer's disease
(Springer, 2022)Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous ...
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Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity
(Wiley, 2023-11)INTRODUCTION Neuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin-3 ...
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Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration
(Nature, 2017)Traumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in Western society, with an ...
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Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease.
(Springer, 2023)Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions ...
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Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
(Springer Nature, 2022)The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are ...
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Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease
(Springer, 2019)Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of ...
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Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q10 Deficiency
(Wiley-Blackwell, 2017-07)Coenzyme Q10 (CoQ10) plays a crucial role in mitochondria as an electron carrier within the mitochondrial respiratory chain ...
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Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
(Springer Nature, 2016-10-19)Glioma cells recruit and exploit microglia (the resident immune cells of the brain) for their proliferation and invasion ...
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Glutaredoxins are essential for stress adaptation in the cyanobacterium Synechocystis sp. PCC 6803
(Frontiers media, 2013)Glutaredoxins are small redox proteins able to reduce disulfides and mixed disulfides between GSH and proteins. Synechocystis ...
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HERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study
(Frontiers Media, 2016)The spontaneous mutation tambaleante is caused by the Gly483Glu substitution in the highly conserved N terminal RCC1-like ...
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HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory
(Frontiers Media, 2020)Mutations in the human HERC1 E3 ubiquitin ligase protein develop intellectual disability. The tambaleante (tbl) mouse ...
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HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System
(Springer, 2018-03-30)A missense mutation in HERC1 provokes loss of cerebellar Purkinje cells, tremor, and unstable gait in tambaleante (tbl) ...
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How the Local Geometry of the Cu-Binding Site Determines the Thermal Stability of Blue Copper Proteins
(Elsevier, 2011-01)Identifying the factors that govern the thermal resistance of cupredoxins is essential for understanding their folding and ...
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Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease
(MDPI, 2020)Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s ...
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Hydroxytyrosol and Parkinson’s disease: protective actions against alpha-synuclein toxicity
(Medknow Publications, 2024-07)