Listar Artículos (Bioquímica y Biología Molecular) por fecha de publicación
Mostrando ítems 21-40 de 223
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Inflammatory animal model for parkinson’s disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons
(A. Conti and A. Lewen, 2011)We have developed an animal model of degeneration of the nigrostriatal dopaminergic neurons, the neuronal system involved in ...
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Synaptic defects in spinal muscular atrophy animal models
(Wiley, 2011)Proximal spinal muscular atrophy, the most frequent genetic cause of childhood lethality, is caused by homozygous loss ...
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Marine carotenoids: Biological functions and commercial applications
(Multidisciplinary Digital Publishing Institute (MDPI), 2011)Carotenoids are the most common pigments in nature and are synthesized by all photosynthetic organisms and fungi. Carotenoids ...
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Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
(Hindawi Publishing Corporation, 2011)Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of ...
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Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model
(American Society for Biochemistry and Molecular Biology Inc., 2011)Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, ...
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How the Local Geometry of the Cu-Binding Site Determines the Thermal Stability of Blue Copper Proteins
(Elsevier, 2011-01)Identifying the factors that govern the thermal resistance of cupredoxins is essential for understanding their folding and ...
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Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients
(Elsevier, 2011-01)We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced ...
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Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse
(SOC NEUROSCIENCE, 2011-02-09)Synchronous neurotransmitter releaseis a highly regulated processthattakes place at specializations atthe presynapticmembrane ...
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Caspase signalling controls microglia activation and neurotoxicity
(Springer Nature, 2011-04-11)Activation of microglia and inflammation-mediated neurotoxicity are suggested to play a decisive role in the pathogenesis ...
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Folic acid supplementation: some practical aspects
(Federation of Anti-Aging Medicine Societies, 2012)Since 1956, when Harman first postulated the free radical theory of aging, numerous studies have been carried out to test ...
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Metformin inhibits glutaminase activity and protects against hepatic encephalopathy
(2012)Aim: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective ...
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Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
(Springer, 2012)Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease ...
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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
(2012)Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies ...
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In vitro and in Vivo Protection by Melatonin Against the Decline of Elongation Factor-2 Caused by Lipid Peroxidation: Preservation of Protein Synthesis
(Wiley-Blackwell, 2012)As organisms age, a considerable decrease in protein synthesis takes place in all tissues. Among the possible causes of ...
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Transcription of Liver X Receptor Is Down-Regulated by 15-Deoxy-Δ12,14-Prostaglandin J2 through Oxidative Stress in Human Neutrophils
(Public Library of Science, 2012)Liver X receptors (LXRs) are ligand-activated transcription factors of the nuclear receptor superfamily. They play ...
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Potential use of adipose tissue stem cells in the control of aging
(Federation of Anti-Aging Medicine Societies, 2012)Cell therapy with adult stem cells is a new battle front for the control of aging. Before being used for this purpose, we ...
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In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology
(BioMed Central, 2013)Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) ...