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Mostrando ítems 1-10 de 24
Artículo
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
(Frontiers Media, 2021)
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. In this sense, synaptic dysfunction and loss have been established as the pathological ...
Artículo
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology
(BioMed Central, 2013)
Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, ...
Tesis Doctoral
Efectos de la acumulación del péptido Beta amiloide en tejido cerebral de ratones PS1xAPP modelos de la Enfermedad de Alzheimer
(2016-01-15)
Esta enfermedad se ha convertido en el tercer problema de salud más grave en los países desarrollados (detrás de los accidentes cardiovasculares y el cáncer). Existen alrededor de 800.000 enfermos diagnosticados en España ...
Artículo
Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density
(Elsevier, 2011)
To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that ...
Tesis Doctoral
Artículo
Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains
(Public Library of Science, 2014)
The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of soluble extracellular Abeta species, such as monomeric and/or oligomeric Abeta, seems to correlate ...
Artículo
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease
(Nature Research (part of Springer Nature), 2017)
Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors ...
Artículo
Should we open fire on microglia? Depletion models as tools to elucidate microglial role in health and alzheimer’s disease
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Microglia play a critical role in both homeostasis and disease, displaying a wide variety in terms of density, functional markers and transcriptomic profiles along the different brain regions as well as under injury or ...
Tesis Doctoral
Implicación de la disfunción glial en la evolución de la patología en pacientes de Alzheimer
(2021-01-20)
La enfermedad de Alzheimer (EA) es un proceso neurodegenerativo que cursa con un deterioro progresivo de las funciones cognitivas, llegando a ser una enfermedad altamente incapacitante. Actualmente, uno de los principales ...
Tesis Doctoral
Variaciones de la respuesta microglial según el contexto patológico en la Enfermedad de Alzheimer
(2021-04-30)
La Enfermedad de Alzheimer (EA) es un trastorno neurodegenerativo progresivo e irreversible que conlleva un deterioro de las funciones cognitivas, afectando a 35 mill de personas a nivel mundial. Las lesiones histopatológicas ...