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Mostrando ítems 1-10 de 11
Artículo
VEGF expression disparities in brainstem motor neurons of the SOD1GP3A ALS model: Correlations with neuronal vulnerability
(Elsevier, 2024)
Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease characterized by severe muscle weakness mainly due to degeneration and death of motor neurons. A peculiarity of the neurodegenerative processes is ...
Artículo
Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers
(American Chemical Society, 2019)
The formation of misfolded protein oligomers during early stages of amyloid aggregation and the activation of neuroinflammatory responses are two key events associated with neurodegenerative diseases. Although it has been ...
Artículo
Modified level of miR-376a is associated with Parkinson's disease
(Willey, 2020)
Parkinson's disease (PD) is a frequent progressive neurodegenerative disorder. Impaired mitochondrial function is a major feature of sporadic PD. Some susceptibility or causative genes detected in PD are strongly associated ...
Artículo
Editorial: Nanoparticle-Mediated Signaling Rewiring and Reprogramming of Immune Responses
(FRONTIERS MEDIA SA, 2022)
Recent advances on the molecular mechanisms that control immune cells are at the core of the development of better immunomodulatory therapies. For example, these mechanisms may enable T cell manipulation interventions ...
Artículo
Artículo
MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type- I IFN responses via Brd4 and is involved in ALS
(National Academy of Sciences, 2023)
Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease affecting motor neurons and characterized by microglia-mediated neurotoxic inflammation whose underlying mechanisms remain incompletely ...
Artículo
Editorial: SARS-CoV-2 in neurodegenerative diseases
(Frontiers Media S.A., 2024)
In the month of March in the year 2020, an alarming pandemic triggered by the SARS CoV-2 virus, which leads to the development of the notorious COVID-19 disease, was officially declared. The consequences of this coronavirus ...
Artículo
Histomorphogenesis and immunohistochemical study of the bovine pineal gland (Bos taurus) during prenatal development (160 days of gestation to birth)
(Universidad de Murcia. Departamento de Biología Celular e Histología, 2006-10-01)
The ontogenesis of the pineal gland of 20 bovine embryos (Bos taurus) has been analysed from 160 days of gestation to birth by means of optical microscopy and immunohistochemical techniques. For this study, the specimens ...
Artículo
The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity
(IVYSPRING INT PUBL, 2021)
Rationale: We recently demonstrated that the ‘Metabesity’ factor HMG20A regulates islet beta-cell functional maturity and adaptation to physiological stress such as pregnancy and pre-diabetes. HMG20A also dictates ...