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Mostrando ítems 1-10 de 33
Artículo
Post-Translational Modifications of Cytochrome c in Cell Life and Disease
(MDPI, 2020)
Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including neurodegenerative diseases, cardiovascular diseases, and various types of cancer. In mitochondrial ...
Artículo
Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle
(Springer Nature, 2023)
Skeletal muscle is more resilient to ischemia-reperfusion injury than other organs. Tissue specific post-translational modifications of cytochrome c (Cytc) are involved in ischemia-reperfusion injury by regulating mitochondrial ...
Artículo
Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors
(MDPI, 2022)
Hepatobiliary tumors are a group of primary malignancies encompassing the liver, the intra- and extra-hepatic biliary tracts, and the gall bladder. Within the liver, hepatocellular carcinoma (HCC) is the most common type ...
Artículo
Editorial: Weak interactions in molecular machinery volume II
(Frontiers Media S.A., 2023)
Artículo
ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs
(Springer, 2021)
Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Using various biochemical approaches, we have identified members of the CNNM family as direct interacting partners of ADP-ribosylation ...
Artículo
Structural insights into the intracellular region of the human magnesium transport mediator CNNM4
(Multidisciplinary Digital Publishing Institute (MDPI), 2019)
The four member family of “Cyclin and Cystathionine β-synthase (CBS) domain divalent metal cation transport mediators”, CNNMs, are the least-studied mammalian magnesium transport mediators. CNNM4 is abundant in the brain ...
Artículo
Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria
(National Academy of Sciences, 2018)
Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective insulin treatment, but how such posttranslational modification affects mitochondrial metabolism is ...
Artículo
Membraneless organelles: a smart design for metabolic control
(Wiley Online Library, 2021)
While most organelles are surrounded by membranes, cells also contain membraneless organelles, which remain separated in the cell by avoiding the mixture of their components with the surroundings. Actually, liquid–liquid ...
Artículo
Nicotinamide N-methyltransferase (NNMT) regulates the glucocorticoid signaling pathway during the early phase of adipogenesis
(Springer Nature, 2023-05-22)
Obesity is associated with adipose tissue dysfunction through the differentiation and expansion of pre-adipocytes to adipocytes (hyperplasia) and/or increases in size of pre-existing adipocytes (hypertrophy). A cascade of ...
Artículo
Long distance electron transfer through the aqueous solution between redox partner proteins
(Nature Research, 2018)
Despite the importance of electron transfer between redox proteins in photosynthesis and respiration, the inter-protein electron transfer rate between redox partner proteins has never been measured as a function of their ...