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Artículo
Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery
(Elsevier, 2011-10)
Fully homogeneous facial amphiphiles consisting in a cyclodextrin (CD) platform onto which a polycationic cluster and a multi-tail hydrophobic moiety have been installed (polycationic amphiphilic CDs; paCDs) self-organized ...
Artículo
Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties
(The Society, 2019-06-19)
An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate ...
Artículo
Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities
(Royal Society of Chemistry, 2014)
Precise control over the architecture of gene carriers is instrumental to manipulate gene delivery efficiency. Combining cationic centers and carbohydrate motifs into monodisperse architectures has been proposed as a ...
Artículo
Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity
(Royal Society of Chemistry, 2024-03-05)
A novel family of precision-engineered gene vectors with well-defined structures built on trehalose and trehalose-based macrocycles (cyclotrehalans) comprising linear or cyclic polyamine heads have been synthesized through ...