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Artículo
In vitro activities of ketolide HMR 3647, macrolides, and clindamycin against coryneform bacteria
(American Society for Microbiology, 1998-12-01)
The in vitro activity of ketolide HMR 3647 against coryneform bacteria isolated from clinical samples was evaluated. Except against Corynebacterium jeikeium and C. urealyticum, HMR 3647 showed high activity against ...
Artículo
Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum β-lactamases in Spain
(American Society for Microbiology, 2005-05-01)
Clonal dissemination of extended-spectrum -lactamases (ESBL) in 170 Escherichia coli isolates and 70 Klebsiella pneumoniae isolates from a nationwide study of 40 Spanish centers in 2000 was not observed in most centers. ...
Artículo
Comparison of broth microdilution and E-test for susceptibility testing of Neisseria meningitidis
(American Society for Microbiology, 1996)
The susceptibilities of 54 clinical isolates of Neisseria meningitidis to penicillin, cefotaxime, ceftriaxone, cefepime, imipenem, ciprofloxacin, chloramphenicol, and rifampin were determined by the microdilution method ...
Artículo
Activities of imipenem and cephalosporins against clonally related strains of Escherichia coli hyperproducing chromosomal β-lactamase and showing altered porin profiles
(American Society for Microbiology, 2000-09-06)
Forty clonally related clinical isolates of Escherichia coli from hospitalized patients were resistant to cefoxitin (MICs, >256 μg/ml) and ceftazidime (MICs, 32 to 256 μg/ml) and were intermediate or resistant to cefotaxime ...
Artículo
Roles of β-Lactamases and Porins in Activities of Carbapenems and Cephalosporins against Klebsiella pneumoniae
(American Society for Microbiology, 1999-07-01)
Two clinical isolates of extended-spectrum β-lactamase (ESBL)- producing Klebsiella pneumoniae were noted to be less susceptible than expected to imipenem. Both were missing outer membrane proteins that serve as channels ...
Artículo
Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1
(American Society for Microbiology, 2007-06-01)
The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant ...
Artículo
Detection of plasmid-mediated quinolone resistance genes in clinical isolates of Enterobacter spp. in Spain
(American Society for Microbiology, 2009)
We have studied by PCR and DNA sequencing the presence of the qnrA, qnrB, qnrS, aac(6′)-Ib-cr, qepA, intI1, and ISCR1 genes in 200 clinical isolates of Enterobacter cloacae (n = 153) and E. aerogenes (n = 47) consecutively ...
Artículo
Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum β-lactamase production
(American Society for Microbiology, 2002-12-01)
The relationships between porin deficiency, active efflux of fluoroquinolones, and extended-spectrum β-lactamase (ESBL) production were determined for 53 clinical isolates of Klebsiella pneumoniae. Thirty-two ESBL-positive ...
Artículo
Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes
(American Society for Microbiology, 1999-01-01)
We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to ...
Artículo
A multinational, preregistered cohort study of β-lactam/β-lactamase inhibitor combinations for treatment of bloodstream infections due to extended-spectrum-β-lactamase-producing enterobacteriaceae
(American Society for Microbiology, 2016-07-01)
The spread of extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) is leading to increased carbapenem consumption. Alternatives to carbapenems need to be investigated. We investigated whether ...