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Tesis Doctoral
Tesis Doctoral
Tesis Doctoral
Resistencia a quinolonas mediada por plásmido en enterobacteriaceae
(2006)
En 1998, se describió por primera vez resistencia a quinolonas transmisible horizontalmente mediante un plásmido conjugativo. La diseminación horizontal de mecanismos de resistencia a fluoroquinolonas abre la posibilidad ...
Artículo
Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants
(BioMed Central, 2008)
Background Predicting antibiotic resistance before it emerges at clinical settings constitutes a novel approach for preventing and fighting resistance of bacterial pathogens. To analyse the possibility that novel ...
Artículo
Bovine tuberculosis in Doñana Biosphere Reserve: The role of wild ungulates as disease reservoirs in the last Iberian lynx strongholds
(Public Library of Science, 2008)
Doñana National Park (DNP) in southern Spain is a UNESCO Biosphere Reserve where commercial hunting and wildlife artificial feeding do not take place and traditional cattle husbandry still exists. Herein, we hypothesized ...
Artículo
Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1
(American Society for Microbiology, 2007-06-01)
The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant ...
Artículo
Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes
(American Society for Microbiology, 2006-09-01)
The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 reached intracellular concentrations 10 times higher than the extracellular concentrations reached. ...
Tesis Doctoral
Betalactamasas de espectro extendido en enterobacterias aisladas de muestras clínicas de hospitales españoles
(2007-02-06)
En 1985, se describió la primera betalactamasa de espectro extendido (BLEE). En España la primera BLEE fue descrita en 1988. Desde entonces estas betalactamasas se han diseminado por todo el mundo, gracias a la movilidad ...
Tesis Doctoral
Artículo
Detection of plasmid-mediated quinolone resistance genes in clinical isolates of Enterobacter spp. in Spain
(American Society for Microbiology, 2009)
We have studied by PCR and DNA sequencing the presence of the qnrA, qnrB, qnrS, aac(6′)-Ib-cr, qepA, intI1, and ISCR1 genes in 200 clinical isolates of Enterobacter cloacae (n = 153) and E. aerogenes (n = 47) consecutively ...