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Artículo
The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne Syndrome-like phenotypes
(Public Library of Science, 2014)
The eukaryotic TFIIH complex is involved in Nucleotide Excision Repair and transcription initiation. We analyzed three yeast mutations of the Rad3/XPD helicase of TFIIH known as rem (recombination and mutation phenotypes). ...
Capítulo de Libro
The Sister-Chromatid Exchange Assay in Human Cells
(Humana, 2020)
The semiconservative nature of DNA replication allows the differential labeling of sister chromatids that isthe fundamental requirement to perform the sister-chromatid exchange (SCE) assay. SCE assay is apowerful technique ...
Capítulo de Libro
Detection of DNA Double-Strand Breaks byγ-H2AX Immunodetection
(Humana, 2020)
DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage and a cause of geneticinstability as they can lead to mutations, genome rearrangements, or loss of genetic material when notproperly repaired. ...