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Mostrando ítems 11-20 de 59
Artículo
Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing
(Elsevier, 2021)
Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation. ...
Artículo
Surface modulation of single-walled carbon nanotubes for selective bacterial cell agglutination
(Dove Medical Press, 2019)
Background: Bacterial resistance to antibiotics is one of the biggest challenges facing medicine today. Anti-adhesive therapy, using inhibitors of bacterial adhesion to epithelial cells, one of the first stages of ...
Artículo
Comparative transcriptomic analysis unveils interactions between the regulatory CarS protein and light response in Fusarium
(BMC, 2019)
Background The orange pigmentation of the agar cultures of many Fusarium species is due to the production of carotenoids, terpenoid pigments whose synthesis is stimulated by light. The genes of the carotenoid pathway and ...
Artículo
Special Issue: Type III Secretion Systems in Human/Animal Pathogenic Bacteria
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Artículo
An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination
(American Society for Microbiology, 2006)
THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. The lack of a functional THO complex impairs transcription, leads to transcriptiondependent ...
Artículo
Increased sensitivity to protein synthesis inhibitors in cells lacking tmRNA
(Cold Spring Harbor Laboratory Press, 2001)
tmRNA (also known as SsrA or 10Sa RNA) is involved in a trans-translation reaction that contributes to the recycling of stalled ribosomes at the 3′ end of an mRNA lacking a stop codon or at an internal mRNA cluster of rare ...
Artículo
Enhanced Gene Regulation by Cooperation between mRNA Decay and Gene Transcription
(Elsevier, 2023)
It has become increasingly clear in the last few years that gene expression in eukaryotes is not a linear process from mRNA synthesis in the nucleus to translation and degradation in the cytoplasm, but works as a circular ...
Artículo
Genome expression analysis of nonproliferating intracellular Salmonella enterica serovar ty phimurium unravels an acid pH-dependent PhoP-PhoQ response essential for dormancy
(American Society for Microbiology, 2013-01)
Genome-wide expression analyses have provided clues on how Salmonella proliferates inside cultured macrophages and epithelial cells. However, in vivo studies show that Salmonella does not replicate massively within host ...
Artículo
The NEL Family of Bacterial E3 Ubiquitin Ligases
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Some pathogenic or symbiotic Gram-negative bacteria can manipulate the ubiquitination system of the eukaryotic host cell using a variety of strategies. Members of the genera Salmonella, Shigella, Sinorhizobium, and Ralstonia, ...
Artículo
A new connection of mRNP biogenesis and export with transcription-coupled repair
(Oxford University Press, 2007)
Although DNA repair is faster in the transcribed strand of active genes, little is known about the possible contribution of mRNP biogenesis and export in transcription-coupled repair (TCR). Interestingly, mutants of THO, ...