Buscar
Mostrando ítems 1-5 de 5
Artículo
The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants
(American Society for Microbiology, 2009)
Cotranscriptional R-loops are formed in yeast mutants of the THO complex, which functions at the interface between transcription and mRNA export. Despite the relevance of R-loops in transcription-associated recombination, the ...
Artículo
The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability
(American Society for Cell Biology, 2008)
The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in yeast. mRNA export factors such as Thp1-Sac3 also affect genome integrity, but their mutations have ...
Artículo
Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex
(National Academy of Sciences, 2007)
Activation-induced cytidine deaminase (AID) is a B cell enzyme essential for Ig somatic hypermutation and class switch recombination. AID acts on ssDNA, and switch regions of Ig genes, a target of AID, form R-loops that ...
Artículo
Chromosomal translocations caused by either Pol32-dependent or Pol32-independent triparental break-induced replication
(American Society for Microbiology, 2009)
Double-strand breaks (DSBs) are harmful DNA lesions that can generate chromosomal rearrangements or chromosome losses if not properly repaired. Despite their association with a number of genetic diseases and cancer, the ...