Listar Artículos (Genética) por título
Mostrando ítems 363-382 de 460
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TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells
(Springer Nature, 2019)The epithelial-to-mesenchymal transition (EMT) and its reversion (MET) are related to tumor cell dissemination and migration, ...
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TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage
(Public Library of Science, 2020)TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural resemblance to heterogeneous ...
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TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription
(Nature Research, 2023-11-09)DNA topoisomerase I (TOP1) removes torsional stress by transiently cutting one DNA strand. Such cuts are rejoined by TOP1 ...
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TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage
(American Society for Biochemistry and Molecular Biology, 2011-01-07)Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand ...
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Tem1 localization to the spindle pole bodies is essential for mitotic exit and impairs spindle checkpoint function
(Rockefeller University Press, 2011)The mitotic exit network (MEN) is a signaling cascade that triggers inactivation of the mitotic cyclin-dependent kinases ...
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Terminal osteoblast differentiation, mediated by runx2 and p27 KIP1, is disrupted in osteosarcoma
(Rockefeller University Press, 2004)The molecular basis for the inverse relationship between differentiation and tumorigenesis is unknown. The function of ...
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TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress
(Oxford University Press, 2012)Transcription factor IIS (TFIIS) stimulates RNA cleavage by RNA polymerase II by allowing backtracked enzymes to resume ...
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The Beak of Eukaryotic Ribosomes: Life, Work and Miracles
(MDPI, 2024-07-22)Ribosomes are not totally globular machines. Instead, they comprise prominent structural protrusions and a myriad of ...
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The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation
(Taylor & Francis, 2022)The small ribosomal subunit protein Rps15/uS19 is involved in early nucleolar ribosome biogenesis and subsequent nuclear ...
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The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development
(Public Library of Science, 2012)THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing ...
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The CarO rhodopsin of the fungus Fusarium fujikuroi is a light-driven proton pump that retards spore germination
(Nature Publishing Group, 2015)Rhodopsins are membrane-embedded photoreceptors found in all major taxonomic kingdoms using retinal as their chromophore. ...
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The carp lncrna is a cars-related regulatory element with broad effects on the fusarium fujikuroi transcriptome
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)Carotenoid biosynthesis in the fungus Fusarium fujikuroi is regulated by environmental factors, with light being the main ...
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The Cell Wall Integrity Pathway Contributes to the Early Stages of Aspergillus Fumigatus Asexual Development
(American Society for Microbiology, 2020)Aspergillus fumigatus is a major cause of human disease. The survival of this fungus is dependent on the cell wall ...
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The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons
(Oxford University Press, 2016)We analyzed 80 different genomic experiments, and found a positive correlation between both RNA polymerase II transcription ...
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The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
(Nature Research, 2023)Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large ...
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The COP9 signalosome is vital for timely repair of DNA double-strand breaks
(Oxford University Press, 2015)The DNA damage response is vigorously activated by DNA double-strand breaks (DSBs). The chief mobilizer of the DSB response ...
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The dedicated chaperone acl4 escorts ribosomal protein rpl4 to its nuclear pre-60s assembly site
(Public Library of Science, 2015)Ribosomes are the highly complex macromolecular assemblies dedicated to the synthesis of all cellular proteins from mRNA ...
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The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins
(EMBO Press, 2019-07-24)Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how ...