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dc.contributor.advisor
dc.creatorÁvila Román, Francisco Javieres
dc.creatorTalero Barrientos, Elena Mªes
dc.creatorAlcaide Molina, Antonio Javieres
dc.creatorReyes, Carolina de loses
dc.creatorZubía, Evaes
dc.creatorGarcía-Mauriño Ruiz-Berdejo, Sofíaes
dc.creatorMotilva Sánchez, Virginiaes
dc.date.accessioned2020-06-28T19:44:51Z
dc.date.available2020-06-28T19:44:51Z
dc.date.issued2014
dc.identifier.citationÁvila Román, F.J., Talero Barrientos, E.M., Alcaide Molina, A.J., Reyes, C.d.l., Zubía, E., García-Mauriño Ruiz-Berdejo, S. y Motilva Sánchez, V. (2014). Preventive effect of the microalga Chlamydomonas debaryana on the acute phase of experimental colitis in rats. British Journal of Nutrition, 112 (7), 1055-1064.
dc.identifier.issn1475-2662es
dc.identifier.urihttps://hdl.handle.net/11441/98355
dc.description.abstractInflammatory bowel diseases (IBD) are characterised by chronic uncontrolled inflammation of intestinal mucosa. Diet and nutritional factors have emerged as possible interventions for IBD. Microalgae are rich sources of n-3 PUFA and derived oxylipins. Oxylipins are lipid mediators involved in the resolution of many inflammatory disorders. The aim of the present study was to investigate the effects of the oxylipin-containing biomass of the microalga Chlamydomonas debaryana and its major oxylipin constituent, (9Z,11E,13S,15Z)-13-hydroxyoctadeca-9,11,15-trienoic acid ((13S)-HOTE), on acute 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. Lyophilised microalgal biomass and (13S)-HOTE were administered by oral route 48, 24 and 1 h before the induction of colitis and 24 h later, and the rats were killed after 48 h. The treatment with the lyophilised microalga and (13S)-HOTE improved body-weight loss and colon shortening, as well as attenuated the extent of colonic damage and increased mucus production. Cellular neutrophil infiltration, with the subsequent increase in myeloperoxidase levels induced by TNBS, were also reduced after the administration of the lyophilised microalga or (13S)-HOTE. The anti-inflammatory effects of these treatments were confirmed by the inhibition of colonic TNF-α production. Moreover, lyophilised microalga or (13S)-HOTE down-regulated cyclo-oxygenase-2 and inducible nitric oxide synthase expression. The present study was the first to show the prophylactic effects of a lyophilised biomass sample of the microalga C. debaryana and the oxylipin (13S)-HOTE on TNBS-induced acute colitis in rats. Our findings suggest that the microalga C. debaryana or derived oxylipins could be used as nutraceuticals in the treatment of the active phase of IBD.es
dc.description.sponsorshipEspaña Ministerio de Ciencia Innovación, Gobierno de España (grant no. IPT-2011-1370-060000)es
dc.formatapplication/pdfes
dc.format.extent10 p.es
dc.language.isoenges
dc.publisherCambridge University Presses
dc.relation.ispartofBritish Journal of Nutrition, 112 (7), 1055-1064.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectOxylipinses
dc.subject(9Z,11E,13S,15Z)-13-Hydroxyoctadeca-9,11,15-trienoic acid: Microalgaees
dc.subject2,4,6-Trinitrobenzenesulfonic acid-induced colitis: PUFAes
dc.subjectResolution of intestinal inflammationes
dc.titlePreventive effect of the microalga Chlamydomonas debaryana on the acute phase of experimental colitis in ratses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Biología Vegetal y Ecologíaes
dc.relation.projectIDgrant no. IPT-2011-1370-060000es
dc.relation.publisherversionhttps://doi.org/10.1017/S0007114514001895es
dc.identifier.doi10.1017/S0007114514001895es
dc.journaltitleBritish Journal of Nutritiones
dc.publication.volumen112es
dc.publication.issue7es
dc.publication.initialPage1055es
dc.publication.endPage1064es
dc.contributor.funderMinisterio de Ciencia e Innovación (MICIN). Españaes

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