Artículo
Sawtooth patterns in force-extension curves of biomolecules: An equilibrium-statistical-mechanics theory
Autor/es | Prados Montaño, Antonio
Carpio, A. Bonilla, L.L. |
Departamento | Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear |
Fecha de publicación | 2013 |
Fecha de depósito | 2020-05-13 |
Publicado en |
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Resumen | We analyze the force-extension curve for a general class of systems, which are described at the mesoscopic
level by a free energy depending on the extension of its components. Similarly to what is done in real experiments,
the ... We analyze the force-extension curve for a general class of systems, which are described at the mesoscopic level by a free energy depending on the extension of its components. Similarly to what is done in real experiments, the total length of the system is the controlled parameter. This imposes a global constraint in the minimization procedure leading to the equilibrium values of the extensions. As a consequence, the force-extension curve has multiple branches in a certain range of forces. The stability of these branches is governed by the free energy: there are a series of first-order phase transitions at certain values of the total length, in which the free energy itself is continuous but its first derivative, the force, has a finite jump. This behavior is completely similar to that observed in real experiments with biomolecules like proteins and with other complex systems |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España |
Identificador del proyecto | FIS2011- 24460 (A.P.), No. FIS2011-28838-C02-0 |
Cita | Prados Montaño, A., Carpio, . y Bonilla, .L. (2013). Sawtooth patterns in force-extension curves of biomolecules: An equilibrium-statistical-mechanics theory. Physical Review E, 88 (1), 012704-1-012704-4. |
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