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Artículo
Targeting mTORs by omega-3 fatty acids: a possible novel therapeutic strategy for neurodegeneration?
Autor/es | Shirooie, Samira
Nabavi, Seyed Fazel Dehpour, Ahmad R. Belwal, Tarun Habtemariam, Solomon Argüelles Castilla, Sandro Nabavi, Seyed Mohammad |
Coordinador/Director | Nabavi, Seyed Mohammad |
Departamento | Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2018-09 |
Fecha de depósito | 2020-05-08 |
Publicado en |
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Resumen | Neurodegenerative diseases (NDs) such as Parkinson's (PD), Alzheimer's (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) cause significant world-wide morbidity and mortality. To date, there is no ... Neurodegenerative diseases (NDs) such as Parkinson's (PD), Alzheimer's (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) cause significant world-wide morbidity and mortality. To date, there is no drug of cure for these, mostly age-related diseases, although approaches in delaying the pathology and/or giving patients some symptomatic relief have been adopted for the last few decades. Various studies in recent years have shown the beneficial effects of omega-3 poly unsaturated fatty acids (PUFAs) through diverse mechanisms including anti-inflammatory effects. This review now assesses the potential of this class of compounds in NDs therapy through specific action against the mammalian target of rapamycin (mTOR) signaling pathway. The role of mTOR in neurodegenerative diseases and targeted therapies by PUFAs are discussed. |
Cita | Shirooie, S., Nabavi, S.F., Dehpour, A.R., Belwal, T., Habtemariam, S., Argüelles Castilla, S. y Nabavi, S.M. (2018). Targeting mTORs by omega-3 fatty acids: a possible novel therapeutic strategy for neurodegeneration?. Pharmacological Research, 135, 37-48. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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mTOROmega3.pdf | 905.4Kb | [PDF] | Ver/ | |