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dc.creatorEnterría Morales, Danieles
dc.creatorLópez López, Ivettees
dc.creatorLópez Barneo, Josées
dc.creatorD’Anglemont de Tassigny, Xavieres
dc.date.accessioned2020-04-30T11:27:58Z
dc.date.available2020-04-30T11:27:58Z
dc.date.issued2016-10-14
dc.identifier.issn1932-6203es
dc.identifier.urihttps://hdl.handle.net/11441/96037
dc.description.abstractGender difference in Parkinson’s disease (PD) suggests that female sex steroids may promote dopaminergic neuron survival and protect them from degeneration. The glial cell line-derived neurotrophic factor (GDNF) is believed to be dopaminotrophic; thus it is considered as a potential therapeutic target in PD. Additionally, GDNF is endogenously synthetized in the caudate/putamen of humans and striatum in rodents. A neuroprotective role of estrogens on the nigrostriatal pathway via the stimulation of GDNF has been proposed. Since the GDNF-producing parvalbumin (Parv) interneurons express the estrogen receptor alpha in the mouse striatum, we sought to determine whether ectopic estrogenic compound mod- ulates the GDNF synthesis in mice. Using an ovariectomized-estradiol (E 2 ) replacement regimen, which reliably generates a rise of plasma estradiol, we assessed the effects of dif- ferent levels of E 2 on the activation of striatal neuronal populations, and GDNF production. A strong correlation was found between plasma E 2 and the expression of the immediate early gene cFos in the striatum, as well as in other cortical regions. However, moderate and high E 2 treatments failed to induce any striatal GDNF mRNA and protein synthesis. High E 2 only stimulates cFos induction in a low percentage of striatal Parv neurons whereas the majority of cFos-positive cells are medium spiny neurons. Activation of these projecting neurons by E 2 suggests a role of circulating sex steroids in the modulation of striatal neural pathways.es
dc.description.sponsorshipInstituto de Salud Carlos III, Miguel Servet Asociación CP12- 03217 (XDADT)es
dc.description.sponsorshipMinisterio de Economı́a y Competitividad: Plan Estatal de Investigación Cientı́fica y Técnica y de Innovación 2013-2016 (JLB)es
dc.formatapplication/pdfes
dc.format.extent17es
dc.language.isoenges
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectStriatal GDNF Productiones
dc.subjectParkinson’s diseasees
dc.subjectMRNA and protein synthesises
dc.subjectFemale Mousees
dc.titleStriatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan- Neuronal Activation in the Female Mouse.es
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.identifier.doi10.1371/journal.pone.0164391es
dc.contributor.groupUniversidad de Sevilla. CTS516: Fisiologia celular y biofisicaes
dc.journaltitlePlos Onees
dc.publication.volumen11es
dc.publication.issue10es

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