Show simple item record


dc.creatorEnterría Morales, Danieles
dc.creatorLópez López, Ivettees
dc.creatorLópez Barneo, Josées
dc.creatorD’Anglemont de Tassigny, Xavieres
dc.description.abstractGender difference in Parkinson’s disease (PD) suggests that female sex steroids may promote dopaminergic neuron survival and protect them from degeneration. The glial cell line-derived neurotrophic factor (GDNF) is believed to be dopaminotrophic; thus it is considered as a potential therapeutic target in PD. Additionally, GDNF is endogenously synthetized in the caudate/putamen of humans and striatum in rodents. A neuroprotective role of estrogens on the nigrostriatal pathway via the stimulation of GDNF has been proposed. Since the GDNF-producing parvalbumin (Parv) interneurons express the estrogen receptor alpha in the mouse striatum, we sought to determine whether ectopic estrogenic compound mod- ulates the GDNF synthesis in mice. Using an ovariectomized-estradiol (E 2 ) replacement regimen, which reliably generates a rise of plasma estradiol, we assessed the effects of dif- ferent levels of E 2 on the activation of striatal neuronal populations, and GDNF production. A strong correlation was found between plasma E 2 and the expression of the immediate early gene cFos in the striatum, as well as in other cortical regions. However, moderate and high E 2 treatments failed to induce any striatal GDNF mRNA and protein synthesis. High E 2 only stimulates cFos induction in a low percentage of striatal Parv neurons whereas the majority of cFos-positive cells are medium spiny neurons. Activation of these projecting neurons by E 2 suggests a role of circulating sex steroids in the modulation of striatal neural
dc.description.sponsorshipInstituto de Salud Carlos III, Miguel Servet Asociación CP12- 03217 (XDADT)es
dc.description.sponsorshipMinisterio de Economı́a y Competitividad: Plan Estatal de Investigación Cientı́fica y Técnica y de Innovación 2013-2016 (JLB)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.subjectStriatal GDNF Productiones
dc.subjectParkinson’s diseasees
dc.subjectMRNA and protein synthesises
dc.subjectFemale Mousees
dc.titleStriatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan- Neuronal Activation in the Female
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.contributor.groupUniversidad de Sevilla. CTS516: Fisiologia celular y biofisicaes
dc.journaltitlePlos Onees

Striatal GDNF Production Is ...2.309MbIcon   [PDF] View/Open  

This item appears in the following collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional