dc.creator | Enterría Morales, Daniel | es |
dc.creator | López López, Ivette | es |
dc.creator | López Barneo, José | es |
dc.creator | D’Anglemont de Tassigny, Xavier | es |
dc.date.accessioned | 2020-04-30T11:27:58Z | |
dc.date.available | 2020-04-30T11:27:58Z | |
dc.date.issued | 2016-10-14 | |
dc.identifier.citation | Enterría Morales, D., López López, I., López Barneo, J. y D’Anglemont de Tassigny, X. (2016). Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan- Neuronal Activation in the Female Mouse.. Plos One, 11 (10) | |
dc.identifier.issn | 1932-6203 | es |
dc.identifier.uri | https://hdl.handle.net/11441/96037 | |
dc.description.abstract | Gender difference in Parkinson’s disease (PD) suggests that female sex steroids may promote dopaminergic neuron survival and protect them from degeneration. The glial cell line-derived neurotrophic factor (GDNF) is believed to be dopaminotrophic; thus it is considered as a potential therapeutic target in PD. Additionally, GDNF is endogenously synthetized in the caudate/putamen of humans and striatum in rodents. A neuroprotective role of estrogens on the nigrostriatal pathway via the stimulation of GDNF has been proposed. Since
the GDNF-producing parvalbumin (Parv) interneurons express the estrogen receptor alpha
in the mouse striatum, we sought to determine whether ectopic estrogenic compound mod-
ulates the GDNF synthesis in mice. Using an ovariectomized-estradiol (E 2 ) replacement
regimen, which reliably generates a rise of plasma estradiol, we assessed the effects of dif-
ferent levels of E 2 on the activation of striatal neuronal populations, and GDNF production.
A strong correlation was found between plasma E 2 and the expression of the immediate
early gene cFos in the striatum, as well as in other cortical regions. However, moderate and
high E 2 treatments failed to induce any striatal GDNF mRNA and protein synthesis. High E 2 only stimulates cFos induction in a low percentage of striatal Parv neurons whereas the
majority of cFos-positive cells are medium spiny neurons. Activation of these projecting
neurons by E 2 suggests a role of circulating sex steroids in the modulation of striatal neural pathways. | es |
dc.description.sponsorship | Instituto de Salud Carlos III, Miguel Servet Asociación CP12- 03217 (XDADT) | es |
dc.description.sponsorship | Ministerio de Economı́a y Competitividad: Plan Estatal de Investigación Cientı́fica y Técnica y de Innovación 2013-2016 (JLB) | es |
dc.format | application/pdf | es |
dc.format.extent | 17 | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Plos One, 11 (10) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Striatal GDNF Production | es |
dc.subject | Parkinson’s disease | es |
dc.subject | MRNA and protein synthesis | es |
dc.subject | Female Mouse | es |
dc.title | Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan- Neuronal Activation in the Female Mouse. | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.identifier.doi | 10.1371/journal.pone.0164391 | es |
dc.contributor.group | Universidad de Sevilla. CTS516: Fisiologia celular y biofisica | es |
dc.journaltitle | Plos One | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 10 | es |