p53 and FBXW7: Sometimes Two Guardians Are Worse than One

Galindo Moreno, María; Giráldez Macías, Servando; Limón Mortés, María Cristina; Belmonte Fernández, Alejandro; Sáez, Carmen; Japón, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco

doi:10.3390/cancers12040985

Artículo

dc.creator	Galindo Moreno, María	es
dc.creator	Giráldez Macías, Servando	es
dc.creator	Limón Mortés, María Cristina	es
dc.creator	Belmonte Fernández, Alejandro	es
dc.creator	Sáez, Carmen	es
dc.creator	Japón, Miguel Ángel	es
dc.creator	Tortolero García, María Dolores	es
dc.creator	Romero Portillo, Francisco	es
dc.date.accessioned	2020-04-30T10:57:13Z
dc.date.available	2020-04-30T10:57:13Z
dc.date.issued	2020
dc.identifier.citation	Galindo Moreno, M., Giráldez Macías, S., Limón Mortés, M.C., Belmonte Fernández, A., Sáez, C., Japón, M.Á.,...,Romero Portillo, F. (2020). p53 and FBXW7: Sometimes Two Guardians Are Worse than One. Cancers, 12 (4 art. 985), 1-5.
dc.identifier.issn	2072-6694	es
dc.identifier.uri	https://hdl.handle.net/11441/96034
dc.description.abstract	Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute to tumorigenesis. Here, we reflect on the results of three laboratories describing the role of FBXW7 in the degradation of p53 and the possible implications of this finding in tumor cell development. We also speculate about the function of FBXW7 as a key player in the cell fate after DNA damage and how this could be exploited in the treatment of cancer disease.	es
dc.description.sponsorship	España, MINECO SAF2017-87358	es
dc.description.sponsorship	España, Junta de Andalucía grant number 2017/BIO-211	es
dc.format	application/pdf	es
dc.format.extent	5 p.	es
dc.language.iso	eng	es
dc.publisher	MDPI	es
dc.relation.ispartof	Cancers, 12 (4 art. 985), 1-5.
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	FBXW7	es
dc.subject	cancer	es
dc.subject	p53	es
dc.subject	proliferation	es
dc.subject	tumor suppressor	es
dc.subject	ubiquitylation	es
dc.title	p53 and FBXW7: Sometimes Two Guardians Are Worse than One	es
dc.type	info:eu-repo/semantics/article	es
dc.type.version	info:eu-repo/semantics/publishedVersion	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es
dc.relation.projectID	SAF2017-87358	es
dc.relation.projectID	grant number 2017/BIO-211	es
dc.relation.publisherversion	http://dx.doi.org/10.3390/cancers12040985	es
dc.identifier.doi	10.3390/cancers12040985	es
dc.journaltitle	Cancers	es
dc.publication.volumen	12	es
dc.publication.issue	4 art. 985	es
dc.publication.initialPage	1	es
dc.publication.endPage	5	es
dc.contributor.funder	Ministerio de Economía y Competitividad (MINECO). España	es
dc.contributor.funder	Junta de Andalucía	es

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