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dc.creatorHuertas Castaño, Carloses
dc.creatorGómez Muñoz, María Ángeleses
dc.creatorPardal Redondo, Ricardoes
dc.creatorVega Moreno, Francisco Manueles
dc.date.accessioned2020-02-17T13:21:17Z
dc.date.available2020-02-17T13:21:17Z
dc.date.issued2019
dc.identifier.citationHuertas Castaño, C., Gómez Muñoz, M.A. Pardal Redondo, R. y Vega Moreno, F.M. (2019). Hypoxia in the Initiation and Progression of Neuroblastoma Tumours. International Journal of Molecular Sciences, 21 (1), 1-15.
dc.identifier.issn1422-0067es
dc.identifier.urihttps://hdl.handle.net/11441/93246
dc.description.abstractNeuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to heterogeneous tumours. Low local or systemic tissue oxygen concentration has emerged as a cellular stimulus with important consequences for tumour initiation, evolution and progression. In neuroblastoma, several evidences point towards a role of hypoxia in tumour initiation during development, tumour cell differentiation, survival and metastatic spreading. However, the heterogeneous nature of the disease, its developmental origin and the lack of suitable experimental models have complicated a clear understanding of the effect of hypoxia in neuroblastoma tumour progression and the molecular mechanisms implicated. In this review, we have compiled available evidences to try to shed light onto this important field. In particular, we explore the effect of hypoxia in neuroblastoma cell transformation and differentiation. We also discuss the experimental models available and the emerging alternatives to study this problem, and we present hypoxia-related therapeutic avenues being explored in the field.es
dc.description.sponsorshipSpanish Ministry of Science and Innovation SAF program (grant number SAF2016-80412-P)es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofInternational Journal of Molecular Sciences, 21 (1), 1-15.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcancer stem cellses
dc.subjecthypoxiaes
dc.subjectneural crest cellses
dc.subjectneuroblastomaes
dc.subjectpaediatric oncologyes
dc.titleHypoxia in the Initiation and Progression of Neuroblastoma Tumourses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Biología Celulares
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.relation.projectIDSAF2016-80412-Pes
dc.relation.publisherversionhttps://doi.org/10.3390/ijms21010039es
dc.identifier.doi10.3390/ijms21010039es
idus.format.extent15 p.es
dc.journaltitleInternational Journal of Molecular Scienceses
dc.publication.volumen21es
dc.publication.issue1es
dc.publication.initialPage1es
dc.publication.endPage15es

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional