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dc.creatorGarcía Miranda, Pabloes
dc.creatorMorón Civanto, Francisco Jesúses
dc.creatorMartínez Olivo, María del Mares
dc.creatorSuárez-Luna, Nelaes
dc.creatorRamírez Lorca, Reposoes
dc.creatorLebrato-Hernández, Lucíaes
dc.creatorLamas-Pérez, Lucíaes
dc.creatorNavarro, Gemmaes
dc.creatorAbril-Jaramillo, Javieres
dc.creatorGarcía Sánchez, María Isabeles
dc.creatorCasado Chocán, José Luises
dc.creatorUclés Sánchez, Antonio Josées
dc.creatorRomera, Mercedeses
dc.creatorEchevarría Irusta, Miriames
dc.creatorDíaz Sánchez, Maríaes
dc.date.accessioned2020-01-17T08:40:16Z
dc.date.available2020-01-17T08:40:16Z
dc.date.issued2019-11-19
dc.identifier.citationGarcía Miranda, P., Morón Civanto, F.J., Martínez Olivo, M.d.M., Suárez-Luna, N., Ramírez Lorca, R., Lebrato-Hernández, L.,...,Díaz Sánchez, M. (2019). Predictive Value of Serum Antibodies and Point Mutations of AQP4, AQP1 and MOG in A Cohort of Spanish Patients with Neuromyelitis Optica Spectrum Disorders. International Journal of Molecular Sciences, 20 (22), 5810.
dc.identifier.issn1422-0067es
dc.identifier.urihttps://hdl.handle.net/11441/91776
dc.description.abstractThe detection of IgG aquaporin-4 antibodies in the serum of patients with Neuromyelitis optica (NMO) has dramatically improved the diagnosis of this disease and its distinction from multiple sclerosis. Recently, a group of patients have been described who have an NMO spectrum disorder (NMOsd) and who are seronegative for AQP4 antibodies but positive for IgG aquaporin-1 (AQP1) or myelin oligodendrocyte glycoprotein (MOG) antibodies. The purpose of this study was to determine whether AQP1 and MOG could be considered new biomarkers of this disease; and if point mutations in the gDNA of AQP4, AQP1 and MOG genes could be associated with the etiology of NMOsd. We evaluated the diagnostic capability of ELISA and cell-based assays (CBA), and analyzed their reliability, specificity, and sensitivity in detecting antibodies against these three proteins. The results showed that both assays can recognize these antigen proteins under appropriate conditions, but only anti-AQP4 antibodies, and not AQP1 or MOG, appears to be a clear biomarker for NMOsd. CBA is the best method for detecting these antibodies; and serum levels of AQP4 antibodies do not correlate with the progression of this disease. So far, the sequencing analysis has not revealed a genetic basis for the etiology of NMOsd, but a more extensive analysis is required before definitive conclusions can be drawn.es
dc.description.sponsorshipMinisterio de Economía y Competitividades
dc.description.sponsorshipFEDER (Grants PI16/01249 y PI16/00493)es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofInternational Journal of Molecular Sciences, 20 (22), 5810.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectdemyelinating diseasees
dc.subjectNMOsdes
dc.subjectAQPses
dc.subjectMOGes
dc.subjectgene sequencinges
dc.subjectimmunohistochemistryes
dc.titlePredictive Value of Serum Antibodies and Point Mutations of AQP4, AQP1 and MOG in A Cohort of Spanish Patients with Neuromyelitis Optica Spectrum Disorderses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.relation.projectIDPI16/01249es
dc.relation.projectIDPI16/00493es
dc.relation.publisherversionhttp://dx.doi.org/10.3390/ijms20225810es
dc.identifier.doi10.3390/ijms20225810es
idus.format.extent17 p.es
dc.journaltitleInternational Journal of Molecular Scienceses
dc.publication.volumen20es
dc.publication.issue22es
dc.publication.initialPage5810es

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional