dc.creator | Pérez Mejías, Gonzalo | es |
dc.creator | Guerra Castellano, Alejandra | es |
dc.creator | Díaz Quintana, Antonio Jesús | es |
dc.creator | Rosa Acosta, Miguel Ángel de la | es |
dc.creator | Díaz Moreno, Irene | es |
dc.date.accessioned | 2019-06-27T06:43:35Z | |
dc.date.available | 2019-06-27T06:43:35Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Pérez Mejías, G., Guerra Castellano, A., Díaz Quintana, A.J., Rosa Acosta, M.Á.d.l. y Díaz Moreno, I. (2019). Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV. Computational and Structural Biotechnology Journal, 17, 654-660. | |
dc.identifier.issn | 2001-0370 | es |
dc.identifier.uri | https://hdl.handle.net/11441/87640 | |
dc.description.abstract | The proper arrangement of protein components within the respiratory electron transport chain is nowadays a matter of intense debate, since altering it leads to cell aging and other related pathologies. Here, we discuss three current views-the so-called solid, fluid and plasticity models-which describe the organization of the main membrane-embedded mitochondrial protein complexes and the key elements that regulate and/or facilitate supercomplex assembly. The soluble electron carrier cytochrome c has recently emerged as an essential factor in the assembly and function of respiratory supercomplexes. In fact, a 'restricted diffusion pathway' mechanism for electron transfer between complexes III and IV has been proposed based on the secondary, distal binding sites for cytochrome c at its two membrane partners recently discovered. This channeling pathway facilitates the surfing of cytochrome c on both respiratory complexes, thereby tuning the efficiency of oxidative phosphorylation and diminishing the production of reactive oxygen species. The well-documented post-translational modifications of cytochrome c could further contribute to the rapid adjustment of electron flow in response to changing cellular conditions. | es |
dc.description.sponsorship | Spanish Ministry of Economy and Competitiveness (BFU2015-71017/BMC MINECO/FEDER and PGC2018-096049-B-I00 BIO/BMC MICINN/FEDER, EU) | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Computational and Structural Biotechnology Journal, 17, 654-660. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cytochrome c | es |
dc.subject | Mitochondria | es |
dc.subject | Phosphorylation | es |
dc.subject | Reactive oxygen species | es |
dc.subject | Respiratory supercomplexes | es |
dc.title | Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Vegetal y Ecología | es |
dc.relation.projectID | BFU2015-71017/BMC MINECO/FEDER and PGC2018-096049-B-I00 BIO/BMC MICINN/FEDER, EU | es |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.csbj.2019.05.002 | es |
dc.identifier.doi | 10.1016/j.csbj.2019.05.002 | es |
idus.format.extent | 6 p. | es |
dc.journaltitle | Computational and Structural Biotechnology Journal | es |
dc.publication.issue | 17 | es |
dc.publication.initialPage | 654 | es |
dc.publication.endPage | 660 | es |