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dc.creatorDíaz Moreno, Irenees
dc.creatorVelázquez Cruz, Alejandroes
dc.creatorCurran French, Seamuses
dc.creatorDíaz Quintana, Antonio Jesúses
dc.creatorRosa Acosta, Miguel Ángel de laes
dc.date.accessioned2019-06-12T14:35:17Z
dc.date.available2019-06-12T14:35:17Z
dc.date.issued2018
dc.identifier.citationDíaz Moreno, I., Velázquez Cruz, A., Curran French, S., Díaz Quintana, A.J. y Rosa Acosta, M.Á.d.l. (2018). Nuclear cytochrome c – a mitochondrial visitor regulating damaged chromatin dynamics. FEBS Letters, 592 (2), 172-178.
dc.identifier.issn0014-5793es
dc.identifier.issn1873-3468es
dc.identifier.urihttps://hdl.handle.net/11441/87386
dc.description.abstractOver the past decade, evidence has emerged suggesting a broader role for cytochrome c (Cyt c) in programmed cell death. Recently, we demonstrated the ability of Cyt c to inhibit the nucleosome assembly activity of histone chaperones SET/template-activating factor Iβ and NAP1-related protein during DNA damage in humans and plants respectively. Here, we hypothesise a dual concentration-dependent function for nuclear Cyt c in response to DNA damage. We propose that low levels of highly cytotoxic DNA lesions – such as double-strand breaks – induce nuclear translocation of Cyt c, leading to the attenuation of nucleosome assembly and, thereby, increasing the time available for DNA repair. If DNA damage persists or is exacerbated, the nuclear Cyt c concentration would exceed a given threshold, causing the haem protein to block DNA remodelling altogether.es
dc.description.sponsorshipMinisterio de Economía, Industria y Competitividad BFU2015-71017/BMCes
dc.description.sponsorshipJunta de Andalucía BIO198es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherWiley-Blackwelles
dc.relation.ispartofFEBS Letters, 592 (2), 172-178.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChromatin remodellinges
dc.subjectCytochrome ces
dc.subjectDNA damage responsees
dc.subjectHistone chaperonees
dc.subjectLow-complexity acidic regiones
dc.titleNuclear cytochrome c – a mitochondrial visitor regulating damaged chromatin dynamicses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Moleculares
dc.relation.projectIDBFU2015-71017/BMCes
dc.relation.projectIDBIO198es
dc.relation.publisherversionhttp://dx.doi.org/10.1002/1873-3468.12959es
dc.identifier.doi10.1002/1873-3468.12959es
idus.format.extent7 p.es
dc.journaltitleFEBS Letterses
dc.publication.volumen592es
dc.publication.issue2es
dc.publication.initialPage172es
dc.publication.endPage178es

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