dc.creator | Romero Campero, Francisco José | es |
dc.creator | Twycross, Jamie | es |
dc.creator | Cao, Hongqing | es |
dc.creator | Blakes, Jonathan | es |
dc.creator | Krasnogor, Natalio | es |
dc.date.accessioned | 2019-05-22T08:04:48Z | |
dc.date.available | 2019-05-22T08:04:48Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Romero Campero, F.J., Twycross, J., Cao, H., Blakes, J. y Krasnogor, N. (2008). A Multiscale Modeling Framework Based on P Systems. En WMC 2008: 9th International Workshop on Membrane Computing (63-77), Edinburgh, Scotland: Springer. | |
dc.identifier.isbn | 978-3-540-95884-0 | es |
dc.identifier.issn | 0302-9743 | es |
dc.identifier.uri | https://hdl.handle.net/11441/86659 | |
dc.description.abstract | Cellular systems present a highly complex organization at
different scales including the molecular, cellular and colony levels. The
complexity at each one of these levels is tightly interrelated. Integrative
systems biology aims to obtain a deeper understanding of cellular systems
by focusing on the systemic and systematic integration of the different
levels of organization in cellular systems.
The different approaches in cellular modeling within systems biology
have been classified into mathematical and computational frameworks.
Specifically, the methodology to develop computational models has been
recently called executable biology since it produces executable algorithms
whose computations resemble the evolution of cellular systems.
In this work we present P systems as a multiscale modeling framework
within executable biology. P system models explicitly specify the
molecular, cellular and colony levels in cellular systems in a relevant and
understandable manner. Molecular species and their structure are represented
by objects or strings, compartmentalization is described using
membrane structures and finally cellular colonies and tissues are modeled
as a collection of interacting individual P systems.
The interactions between the components of cellular systems are described
using rewriting rules. These rules can in turn be grouped together
into modules to characterize specific cellular processes. One of our current
research lines focuses on the design of cell systems biology models
exhibiting a prefixed behavior through the automatic assembly of these
cellular modules. Our approach is equally applicable to synthetic as well
as systems biology. | es |
dc.description.sponsorship | Kingdom's Engineering and Physical Sciences Research Council EP/ E017215/1 | es |
dc.description.sponsorship | Biotechnology and Biological Sciences Research Council/United Kingdom BB/F01855X/1 | es |
dc.description.sponsorship | Biotechnology and Biological Sciences Research Council/United Kingdom BB/D019613/1 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Springer | es |
dc.relation.ispartof | WMC 2008: 9th International Workshop on Membrane Computing (2008), p 63-77 | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | A Multiscale Modeling Framework Based on P Systems | es |
dc.type | info:eu-repo/semantics/conferenceObject | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/submittedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial | es |
dc.relation.projectID | EP/ E017215/1 | es |
dc.relation.projectID | BB/F01855X/1 | es |
dc.relation.projectID | BB/D019613/1 | es |
dc.relation.publisherversion | https://link.springer.com/chapter/10.1007%2F978-3-540-95885-7_5 | es |
dc.identifier.doi | 10.1007/978-3-540-95885-7_5 | es |
dc.contributor.group | Universidad de Sevilla. TIC193: Computación Natural | es |
idus.format.extent | 15 | es |
dc.publication.initialPage | 63 | es |
dc.publication.endPage | 77 | es |
dc.eventtitle | WMC 2008: 9th International Workshop on Membrane Computing | es |
dc.eventinstitution | Edinburgh, Scotland | es |
dc.relation.publicationplace | Berlin | es |