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dc.creatorPerri, Mariaritaes
dc.creatorAiello, Francescaes
dc.creatorCione, Erikaes
dc.creatorCarullo, Gabrielees
dc.creatorMazzotta, Sarahes
dc.creatorCaroleo, Maria Cristinaes
dc.date.accessioned2019-03-29T10:04:13Z
dc.date.available2019-03-29T10:04:13Z
dc.date.issued2019
dc.identifier.citationPerri, M., Aiello, ., Cione, ., Carullo, ., Mazzotta, S. y Caroleo, M.C. (2019). Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds. Frontiers in Molecular Biosciences, 6 (12), 1-5.
dc.identifier.issn2296-889Xes
dc.identifier.urihttps://hdl.handle.net/11441/84916
dc.description.abstracthe triple-negative breast cancer (TNBC) is characterized by a more aggressive nature and poorer prognosis, nowadays none pharmaceutical approach is still available. For this reason, the research of new active compounds and attractive targets represents an interesting field. In this context MDA- MB-231 cell line was selected to evaluate the antiproliferative effects of new [1,2-a]-pyrroloquinoxaline derivatives. The MTT assay revealed that the amine forms of synthesized molecules were more active compared to iminic ones at 72 h of incubation. The antiproliferative effect of the most promising compounds highlighted the formation of autophagic vacuoles.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherFrontiers Mediaes
dc.relation.ispartofFrontiers in Molecular Biosciences, 6 (12), 1-5.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectpyrroloquinoxalineses
dc.subjecttriple-negative breast canceres
dc.subjectautophagyes
dc.subjectantiproliferative activityes
dc.subjectone-pot reactiones
dc.titleInvestigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compoundses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química Orgánica y Farmacéuticaes
dc.relation.publisherversionhttp://dx.doi.org/10.3389/fmolb.2019.00012es
dc.identifier.doi10.3389/fmolb.2019.00012es
idus.format.extent5 p.es
dc.journaltitleFrontiers in Molecular Bioscienceses
dc.publication.volumen6es
dc.publication.issue12es
dc.publication.initialPage1es
dc.publication.endPage5es

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