Artículo
Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds
Autor/es | Perri, Mariarita
Aiello, Francesca Cione, Erika Carullo, Gabriele Mazzotta, Sarah Caroleo, Maria Cristina |
Departamento | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica |
Fecha de publicación | 2019 |
Fecha de depósito | 2019-03-29 |
Publicado en |
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Resumen | he triple-negative breast cancer (TNBC) is characterized by a more aggressive nature and poorer prognosis, nowadays none pharmaceutical approach is still available. For this reason, the research of new active compounds and ... he triple-negative breast cancer (TNBC) is characterized by a more aggressive nature and poorer prognosis, nowadays none pharmaceutical approach is still available. For this reason, the research of new active compounds and attractive targets represents an interesting field. In this context MDA- MB-231 cell line was selected to evaluate the antiproliferative effects of new [1,2-a]-pyrroloquinoxaline derivatives. The MTT assay revealed that the amine forms of synthesized molecules were more active compared to iminic ones at 72 h of incubation. The antiproliferative effect of the most promising compounds highlighted the formation of autophagic vacuoles. |
Cita | Perri, M., Aiello, ., Cione, ., Carullo, ., Mazzotta, S. y Caroleo, M.C. (2019). Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds. Frontiers in Molecular Biosciences, 6 (12), 1-5. |
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