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dc.creatorDíaz Moreno, Irenees
dc.creatorMuñoz López, Francisco Jesúses
dc.creatorFrutos Beltrán, Estrellaes
dc.creatorRosa Acosta, Miguel Ángel de laes
dc.creatorDíaz Quintana, Antonio Jesúses
dc.date.accessioned2019-03-27T09:43:52Z
dc.date.available2019-03-27T09:43:52Z
dc.date.issued2009
dc.identifier.citationDíaz Moreno, I., Muñoz López, F.J., Frutos Beltrán, E., Rosa Acosta, M.Á.d.l. y Díaz Quintana, A.J. (2009). Electrostatic strain and concerted motions in the transient complex between plastocyanin and cytochrome f from the cyanobacterium Phormidium laminosum. Bioelectrochemistry, 77 (1), 43-52.
dc.identifier.issn1567-5394es
dc.identifier.urihttps://hdl.handle.net/11441/84781
dc.description.abstractMany fleeting macromolecular interactions, like those being involved in electron transport, are essential in biology. However, little is known about the behaviour of the partners and their dynamics within their shortlived complex. To tackle such issue, we have performed molecular dynamics simulations on an electron transfer complex formed by plastocyanin and cytochrome f from the cyanobacterium Phormidium laminosum. Besides simulations of the isolated partners, two independent trajectories of the complex were calculated, starting from the two different conformations in the NMR ensemble. The first one leads to a more stable ensemble with a shorter distance between the metal sites of the two partners. The second experiences a significant drift of the complex conformation. Analyses of the distinct calculations show that the conformation of cytochrome f is strained upon binding of its partner, and relaxes upon its release. Interestingly, the principal component analysis of the trajectories indicates that plastocyanin displays a concerted motion with the small domain of cytochrome f that can be attributed to electrostatic interactions between the two proteins.es
dc.description.sponsorshipMinisterio de Ciencia e Innovación BFU2006-01361 BES-2005-10404es
dc.description.sponsorshipJunta de Andalucía BIO-198 P06-CVI-01713es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofBioelectrochemistry, 77 (1), 43-52.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCytochrome fes
dc.subjectDomain motionses
dc.subjectMolecular dynamicses
dc.subjectPlastocyanines
dc.subjectTransient protein complexeses
dc.titleElectrostatic strain and concerted motions in the transient complex between plastocyanin and cytochrome f from the cyanobacterium Phormidium laminosumes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Moleculares
dc.relation.projectIDBFU2006-01361es
dc.relation.projectIDBES-2005-10404es
dc.relation.projectIDBIO-198es
dc.relation.projectIDP06-CVI-01713es
dc.relation.publisherversionhttps://doi.org/10.1016/j.bioelechem.2009.06.003es
dc.identifier.doi10.1016/j.bioelechem.2009.06.003es
idus.format.extent10 p.es
dc.journaltitleBioelectrochemistryes
dc.publication.volumen77es
dc.publication.issue1es
dc.publication.initialPage43es
dc.publication.endPage52es

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