dc.creator | Cukier, Cyprian D. | es |
dc.creator | Hollingworth, David | es |
dc.creator | Martin, Stephen | es |
dc.creator | Kelly, Geoff | es |
dc.creator | Díaz Moreno, Irene | es |
dc.creator | Ramos, Andrés | es |
dc.date.accessioned | 2019-03-26T12:08:16Z | |
dc.date.available | 2019-03-26T12:08:16Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Cukier, C.D., Hollingworth, D., Martin, S., Kelly, G., Díaz Moreno, I. y Ramos, A. (2010). Molecular basis of FIR-mediated c-myc transcriptional control. Nature Structural and Molecular Biology, 17 (9), 1058-1064. | |
dc.identifier.issn | 1545-9993 (impreso) | es |
dc.identifier.issn | 1545-9985 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/84706 | |
dc.description.abstract | The far upstream element (FUSE) regulatory system promotes a peak in the concentration of c-Myc during cell cycle. First, the FBP transcriptional activator binds to the FUSE DNA element upstream of the c-myc promoter. Then, FBP recruits its specific repressor (FIR), which acts as an on/off transcriptional switch. Here we describe the molecular basis of FIR recruitment, showing that the tandem RNA recognition motifs of FIR provide a platform for independent FUSE DNA and FBP protein binding and explaining the structural basis of the reversibility of the FBP-FIR interaction. We also show that the physical coupling between FBP and FIR is modulated by a flexible linker positioned sequentially to the recruiting element. Our data explain how the FUSE system precisely regulates c-myc transcription and suggest that a small change in FBP-FIR affinity leads to a substantial effect on c-Myc concentration. | es |
dc.description.sponsorship | MRC Grant-in-aid U117574558 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Nature Research | es |
dc.relation.ispartof | Nature Structural and Molecular Biology, 17 (9), 1058-1064. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Molecular basis of FIR-mediated c-myc transcriptional control | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular | es |
dc.relation.projectID | U117574558 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1038/nsmb.1883 | es |
dc.identifier.doi | 10.1038/nsmb.1883 | es |
idus.format.extent | 8 p. | es |
dc.journaltitle | Nature Structural and Molecular Biology | es |
dc.publication.volumen | 17 | es |
dc.publication.issue | 9 | es |
dc.publication.initialPage | 1058 | es |
dc.publication.endPage | 1064 | es |