dc.creator | Navarro López, Juan de Dios | es |
dc.creator | Alvarado, Juan Carlos | es |
dc.creator | Márquez Ruiz, Javier | es |
dc.creator | Escudero González, Miguel | es |
dc.creator | Delgado García, José María | es |
dc.creator | Yajeya, Javier | es |
dc.date.accessioned | 2019-02-20T09:48:58Z | |
dc.date.available | 2019-02-20T09:48:58Z | |
dc.date.issued | 2004 | |
dc.identifier.citation | Navarro López, J.d.D., Alvarado, J.C., Márquez Ruiz, J., Escudero González, M., Delgado García, J.M. y Yajeya, J. (2004). A Cholinergic Synaptically Triggered Event Participates in the Generation of Persistent Activity Necessary for Eye Fixation. Journal of Neuroscience, 24 (22), 5109-5118. | |
dc.identifier.issn | 1529-2401 | es |
dc.identifier.uri | https://hdl.handle.net/11441/83260 | |
dc.description.abstract | An exciting topic regarding integrative properties of the nervous system is how transient motor commands or brief sensory stimuli are able to evoke persistent neuronal changes, mainly as a sustained, tonic action potential firing. A persisting firing seems to be necessary for postural maintenance after a previous movement. We have studied in vitro and in vivo the generation of the persistent neuronal activity responsible for eye fixation after spontaneous eye movements. Rat sagittal brainstem slices were used for the intracellular recording of prepositus hypoglossi (PH) neurons and their synaptic activation from nearby paramedian pontine reticular formation (PPRF) neurons. Single electrical pulses applied to the PPRF showed a monosynaptic glutamatergic projection on PH neurons, acting on AMPA-kainate receptors. Train stimulation of the PPRF area evoked a sustained depolarization of PH neurons exceeding (by hundreds of milliseconds) stimulus duration. Both duration and amplitude of this sustained depolarization were linearly related to train frequency. The train-evoked sustained depolarization was the result of interaction between glutamatergic excitatory burst neurons and cholinergic mesopontine reticular fibers projecting onto PH neurons, because it was prevented by slice superfusion with cholinergic antagonists and mimicked by cholinergic agonists. As expected, microinjections of cholinergic antagonists in the PH nucleus of alert behaving cats evoked a gaze-holding deficit consisting of a re-centering drift of the eye after each saccade. These findings suggest that a slow, cholinergic, synaptically triggered event participates in the generation of persistent activity characteristic of PH neurons carrying eye position signals. | es |
dc.description.sponsorship | Unión Europea Grants BI04-CT98-0546 | es |
dc.description.sponsorship | España, Ministerio de Ciencia PB98-0011, BFI2000-00936, BFI2000-1190, y BFI2002-01378 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Society for Neuroscience | es |
dc.relation.ispartof | Journal of Neuroscience, 24 (22), 5109-5118. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | acetyl choline | es |
dc.subject | glutamate | es |
dc.subject | neuronal integrator | es |
dc.subject | prepositus hypoglossi | es |
dc.subject | saccades | es |
dc.subject | oculomotor system | es |
dc.title | A Cholinergic Synaptically Triggered Event Participates in the Generation of Persistent Activity Necessary for Eye Fixation | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.relation.projectID | Grants BI04-CT98-0546 | es |
dc.relation.projectID | PB98-0011, BFI2000-00936, BFI2000-1190, BFI2002-01378 | es |
dc.relation.publisherversion | http://dx.doi.org//10.1523/JNEUROSCI.0235-04.2004 | es |
dc.identifier.doi | doi.org/10.1523/JNEUROSCI.0235-04.2004 | es |
idus.format.extent | 9 p. | es |
dc.journaltitle | Journal of Neuroscience | es |
dc.publication.volumen | 24 | es |
dc.publication.issue | 22 | es |
dc.publication.initialPage | 5109 | es |
dc.publication.endPage | 5118 | es |
dc.contributor.funder | European Union (UE) | |
dc.contributor.funder | Ministerio de Educación y Cultura (MEC). España | |