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dc.creatorFernández Delgado, Ángelaes
dc.creatorLópez López, Manueles
dc.creatorBlanco Arévalo, Danieles
dc.creatorMoyá Morán, María Luisaes
dc.creatorVentosa Ucero, Antonioes
dc.creatorCarrera Sánchez, Cecilioes
dc.creatorRuiz de la Haba, Rafaeles
dc.creatorBernal Pérez, Evaes
dc.creatorLópez-Cornejo, María del Pilares
dc.date.accessioned2019-02-18T09:28:38Z
dc.date.available2019-02-18T09:28:38Z
dc.date.issued2019
dc.identifier.citationFernández Delgado, Á., López López, M., Blanco Arévalo, D., Moyá Morán, M.L., Ventosa Ucero, A., Carrera Sánchez, C.,...,López Cornejo, P. (2019). Optimized Preparation of Levofloxacin Loaded Polymeric Nanoparticles. Pharmaceutics, 11 (2), 1-13.
dc.identifier.issn1999-4923es
dc.identifier.urihttps://hdl.handle.net/11441/83118
dc.description.abstractIn this work, poly(lactic-co-glycolic acid) (PLGA) and chitosan (CS) nanoparticles were synthesized with the purpose of encapsulating levofloxacin (LEV). A thorough study has been carried out in order to optimize the preparation of LEV-loaded polymeric nanoparticles (NPs) suitable for parenteral administration. Changes in the preparation method, in the organic solvent nature, in the pH of the aqueous phase, or in the temperature were investigated. To the authors´ knowledge, a systematic study in order to improve the LEV nanocarrier characteristics and the yield of drug encapsulation has not been carried out to date. The physicochemical characterization of the NPs, their encapsulation efficiency (EE), and the in vitro release of LEV revealed that the best formulation was the emulsion-solvent evaporation method using dichloromethane as organic solvent, which renders suitable LEV loaded PLGA NPs. The morphology of these NPs was investigated using TEM. Their antimicrobial activities against several microorganisms were determined in vitro measuring the minimum inhibitory concentration (MIC). The results show that the use of these loaded LEV PLGA nanoparticles has the advantage of the slow release of the antibiotic, which would permit an increase in the time period between administrations as well as to decrease the side effects of the drug.es
dc.description.sponsorshipJunta de Andalucía, Consejeria de Educación y Ciencia Proyecto de Excelencia P12-FQM-1105, FQM-206 and FQM-274es
dc.description.sponsorshipUniversidad de Sevilla, VI Plan Propio 2018/500es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofPharmaceutics, 11 (2), 1-13.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPLGAes
dc.subjectchitosanes
dc.subjectlevofloxacines
dc.subjectnanoparticleses
dc.titleOptimized Preparation of Levofloxacin Loaded Polymeric Nanoparticleses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química Físicaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Microbiología y Parasitologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Ingeniería Químicaes
dc.relation.projectIDProyecto de Excelencia P12-FQM-1105, FQM-206 and FQM-274es
dc.relation.publisherversionhttp://dx.doi.org/10.3390/pharmaceutics11020057es
dc.identifier.doi10.3390/pharmaceutics11020057es
idus.format.extent13 p.es
dc.journaltitlePharmaceuticses
dc.publication.volumen11es
dc.publication.issue2es
dc.publication.initialPage1es
dc.publication.endPage13es
dc.contributor.funderJunta de Andalucía
dc.contributor.funderJunta de Andalucía
dc.contributor.funderUniversidad de Sevilla
dc.contributor.funderUniversidad de Sevilla

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional