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dc.creatorSahuquillo-Arce, José Migueles
dc.creatorPerpiñán, Héctores
dc.creatorArmero, Carmenes
dc.creatorLópez-Quílez, Antonioes
dc.creatorSelva, Maríaes
dc.creatorAguayo-González, Franciscoes
dc.date.accessioned2018-11-28T17:21:14Z
dc.date.available2018-11-28T17:21:14Z
dc.date.issued2014
dc.identifier.citationSahuquillo-Arce, J.M., Perpiñán, H., Armero, C., López-Quílez, A., Selva, M. y Aguayo González, F. (2014). Bayesian Approach to Urinary ESBL-Producing Escherichia coli. Journal of Pharmacovigilance, 2 (3), 1000133-.
dc.identifier.issn2329-6887es
dc.identifier.urihttps://hdl.handle.net/11441/80611
dc.description.abstractThis is a retrospective study about the prevalence of ESBL-producing Escherichia coli (EEC) in urinary specimens from patients from the Comunitat Valenciana from January 2007 to December 2008. Data were retrieved from RedMIVA, and Bayesian generalized linear mixed models were considered to study the prevalence of EEC with regard to demographical and microbiological factors. The total number of infections considered was 164,502, the amount of urinary isolates was 70,827 belonging to 49,304 different patients, and 5,161 (7.3%) of the urinary isolates were EEC. Three out of four E. coli were isolated in women (76.8%), men showed higher rates of EEC (9.7% in men vs. 6.5% in women). EEC patients were, in average, 10.8 years older, and hospitalization was more frequent (9.9% vs. 6.9%). Resistance to non-β-lactams antimicrobials was higher in EEC. The rates of ciprofloxacin and co-trimoxazol resistance in EEC were 75.5% and 52.0%, respectively, whereas it ranged between 1.4-12.4% for the rest of antimicrobials. Prior EEC infection and hospitalization were the most relevant risk factors and increased the expected EEC probability approximately 400% and 50% respectively. Other infections played an important and positive role too, Enterobacteriaceae, P. aeruginosa and other bacteria being the most relevant elements. Female gender was a protective factor and reduced the risk by approximately 25% while age was an additive risk factor. Finally, an open-access web-based software was constructed to compute the probability that an E. coli in a urinary infection be an EEC from a specific combination of risk factors. This pharmacovigilance tool should prove useful to monitor and control antimicrobial resistance spread.es
dc.description.sponsorshipAll the microbiologist who collaborate with RedMIVAes
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherOMICS Internationales
dc.relation.ispartofJournal of Pharmacovigilance, 2 (3), 1000133-.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPharmacovigilancees
dc.subjectControles
dc.subjectAntimicrobiales
dc.titleBayesian Approach to Urinary ESBL-Producing Escherichia colies
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Ingeniería del Diseñoes
dc.relation.publisherversionhttps://www.omicsonline.org/open-access/bayesian-approach-to-urinary-esblproducing-escherichia-coli-2329-6887-2-133.php?aid=28136es
dc.identifier.doi10.4172/2329-6887.1000133es
dc.contributor.groupUniversidad de Sevilla. TEP022: Diseño Industrial e Ingeniería del Proyecto y la Innovaciónes
idus.format.extent5 p.es
dc.journaltitleJournal of Pharmacovigilancees
dc.publication.volumen2es
dc.publication.issue3es
dc.publication.initialPage1000133es

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