dc.creator | Pinto Pérez, Francisco M. | es |
dc.creator | Bello, A. R. | es |
dc.creator | Gallardo Castro, Manuel | es |
dc.creator | Valladares, Francisco | es |
dc.creator | Almeida, Teresa A. | es |
dc.creator | Tena Sempere, Manuel | es |
dc.creator | Candenas, M. Luz | es |
dc.date.accessioned | 2018-08-06T10:13:01Z | |
dc.date.available | 2018-08-06T10:13:01Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Pinto Pérez, F.M., Bello, A.R., Gallardo Castro, M., Valladares, F., Almeida, T.A., Tena Sempere, M. y Candenas, M.L. (2015). Analysis of the expression of tachykinins and tachykinin receptors in the rat uterus during early pregnancy. (Tesis Doctoral Inédita). Universidad de Sevilla, Sevilla. | |
dc.identifier.issn | 0006-3363 (impreso) | es |
dc.identifier.issn | 1529-7268 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/77862 | |
dc.description.abstract | The peptides of the tachykinin family participate in the
regulation of reproductive function acting at both central and
peripheral levels. Our previous data showed that treatment of
rats with a tachykinin NK3R antagonist caused a reduction of
litter size. In the present study, we analyzed the expression of
tachykinins and tachykinin receptors in the rat uterus during
early pregnancy. Uterine samples were obtained from early
pregnant rats (Days 1–9 of pregnancy) and from nonpregnant
rats during the proestrus stage of the ovarian cycle, and real-
time quantitative RT-PCR, immunohistochemistry, and Western
blot studies were used to investigate the pattern of expression of
tachykinins and tachykinin receptors. We found that all
tachykinins and tachykinin receptors were locally synthesized
in the uterus of early pregnant rats. The expression of substance
P, neurokinin B, and the tachykinin receptors NK1R and NK3R
mRNAs and proteins underwent major changes during the days
around implantation and they were widely distributed in
implantation sites, being particularly abundant in decidual cells.
These findings support the involvement of the tachykinin system
in the series of uterine events that occur around embryo
implantation in the rat. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Society for the Study of Reproduction | es |
dc.relation.ispartof | Biology of Reproduction, 93 (2), 51-58. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Decidua | es |
dc.subject | Early pregnancy | es |
dc.subject | Rat uterus | es |
dc.subject | Tachykinin receptors | es |
dc.subject | Tachykinins | es |
dc.title | Analysis of the expression of tachykinins and tachykinin receptors in the rat uterus during early pregnancy | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.relation.publisherversion | http://dx.doi.org/10.1095/biolreprod.115.130617 | es |
dc.identifier.doi | 10.1095/biolreprod.115.130617 | es |
idus.format.extent | 15 | es |
dc.journaltitle | Biology of Reproduction | es |
dc.publication.volumen | 93 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 51 | es |
dc.publication.endPage | 58 | es |