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dc.creatorUtrilla Alcolea, José Carmeloes
dc.creatorGordillo Martínez, Flora Maríaes
dc.creatorGómez Pascual, Amparoes
dc.creatorFernández-Santos, José Maríaes
dc.creatorGarnacho Montero, Carmenes
dc.creatorVázquez Román, María Victoriaes
dc.creatorMorillo Bernal, Jesúses
dc.creatorGarcía Marín, Mª del Rocíoes
dc.creatorJiménez García, Antonioes
dc.creatorMartín Lacave, Inés Maríaes
dc.date.accessioned2018-05-28T17:30:11Z
dc.date.available2018-05-28T17:30:11Z
dc.date.issued2015
dc.identifier.issn1469-7580es
dc.identifier.urihttps://hdl.handle.net/11441/75281
dc.description.abstractSince their discovery in different human tissues by Zimmermann in 1898, primary cilia have been found in the vast majority of cell types in vertebrates. Primary cilia are considered to be cellular antennae that occupy an ideal cellular location for the interpretation of information both from the environment and from other cells. To date, in mammalian thyroid gland, primary cilia have been found in the thyrocytes of humans and dogs (fetuses and adults) and in rat embryos. The present study investigated whether the existence of this organelle in follicular cells is a general event in the postnatal thyroid gland of different mammals, using both immunolabeling by immunofluorescence and electron microscopy. Furthermore, we aimed to analyse the presence of primary cilia in various thyroid cell lines. According to our results, primary cilia are present in the adult thyroid gland of most mammal species we studied (human, pig, guinea pig and rabbit), usually as a single copy per follicular cell. Strikingly, they were not found in rat or mouse thyroid tissues. Similarly, cilia were also observed in all human thyroid cell lines tested, both normal and neoplastic follicular cells, but not in cultured thyrocytes of rat origin. We hypothesize that primary cilia could be involved in the regulation of normal thyroid function through specific signaling pathways. Nevertheless, further studies are needed to shed light on the permanence of these organelles in the thyroid gland of most species during postnatal life.es
dc.description.sponsorshipJunta de Andalucía. Consejería de Innovación, Ciencia y Empresa CTS-439/2011es
dc.description.sponsorshipJunta de Andalucía. Consejería de Innovación, Ciencia y Empresa CTS-229/2011es
dc.description.sponsorshipJunta de Andalucía. Consejería de Salud PI-0051-2013es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherAnatomical Societyes
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectfollicular cellses
dc.subjectmammalses
dc.subjectprimary ciliaes
dc.subjectthyroid glandes
dc.titleComparative study of the primary cilia in thyrocytes of adult mammalses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Citología e Histología Normal y Patológicaes
dc.identifier.doi10.1111/joa.12360es
dc.contributor.groupUniversidad de Sevilla. CTS439: Sistema Neuroendocrino Difusoes
dc.contributor.groupUniversidda de Sevilla. CTS229: Biopatologia Celulares
idus.format.extent11es
dc.journaltitleJournal of Anatomyes
dc.publication.volumen227es
dc.publication.issue4es
dc.publication.initialPage550es
dc.publication.endPage560es

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