dc.creator | Utrilla Alcolea, José Carmelo | es |
dc.creator | Gordillo Martínez, Flora María | es |
dc.creator | Gómez Pascual, Amparo | es |
dc.creator | Fernández-Santos, José María | es |
dc.creator | Garnacho Montero, Carmen | es |
dc.creator | Vázquez Román, María Victoria | es |
dc.creator | Morillo Bernal, Jesús | es |
dc.creator | García Marín, Mª del Rocío | es |
dc.creator | Jiménez García, Antonio | es |
dc.creator | Martín Lacave, Inés María | es |
dc.date.accessioned | 2018-05-28T17:30:11Z | |
dc.date.available | 2018-05-28T17:30:11Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Utrilla Alcolea, J.C., Gordillo Martínez, F.M., Gómez Pascual, A., Fernández-Santos, J.M., Garnacho Montero, C., Vázquez Román, M.V.,...,Martín Lacave, I.M. (2015). Comparative study of the primary cilia in thyrocytes of adult mammals. Journal of Anatomy, 227 (4), 550-560. | |
dc.identifier.issn | 1469-7580 | es |
dc.identifier.uri | https://hdl.handle.net/11441/75281 | |
dc.description.abstract | Since their discovery in different human tissues by Zimmermann in 1898, primary cilia have been found in the vast majority of cell types in vertebrates. Primary cilia are considered to be cellular antennae that occupy an ideal cellular location for the interpretation of information both from the environment and from other cells. To date, in mammalian thyroid gland, primary cilia have been found in the thyrocytes of humans and dogs (fetuses and adults) and in rat embryos. The present study investigated whether the existence of this organelle in follicular cells is a general event in the postnatal thyroid gland of different mammals, using both immunolabeling by immunofluorescence and electron microscopy. Furthermore, we aimed to analyse the presence of primary cilia in various thyroid cell lines. According to our results, primary cilia are present in the adult thyroid gland of most mammal species we studied (human, pig, guinea pig and rabbit), usually as a single copy per follicular cell. Strikingly, they were not found in rat or mouse thyroid tissues. Similarly, cilia were also observed in all human thyroid cell lines tested, both normal and neoplastic follicular cells, but not in cultured thyrocytes of rat origin. We hypothesize that primary cilia could be involved in the regulation of normal thyroid function through specific signaling pathways. Nevertheless, further studies are needed to shed light on the permanence of these organelles in the thyroid gland of most species during postnatal life. | es |
dc.description.sponsorship | Junta de Andalucía. Consejería de Innovación, Ciencia y Empresa CTS-439/2011 | es |
dc.description.sponsorship | Junta de Andalucía. Consejería de Innovación, Ciencia y Empresa CTS-229/2011 | es |
dc.description.sponsorship | Junta de Andalucía. Consejería de Salud PI-0051-2013 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Anatomical Society | es |
dc.relation.ispartof | Journal of Anatomy, 227 (4), 550-560. | |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | follicular cells | es |
dc.subject | mammals | es |
dc.subject | primary cilia | es |
dc.subject | thyroid gland | es |
dc.title | Comparative study of the primary cilia in thyrocytes of adult mammals | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.identifier.doi | 10.1111/joa.12360 | es |
dc.contributor.group | Universidad de Sevilla. CTS439: Sistema Neuroendocrino Difuso | es |
dc.contributor.group | Universidda de Sevilla. CTS229: Biopatologia Celular | es |
idus.format.extent | 11 | es |
dc.journaltitle | Journal of Anatomy | es |
dc.publication.volumen | 227 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 550 | es |
dc.publication.endPage | 560 | es |