dc.creator | Maya Miles, Douglas | es |
dc.creator | Peñate Salas, Xenia | es |
dc.creator | Sanmartín Olmo, Trinidad | es |
dc.creator | Jourquin, Frederic | es |
dc.creator | Muñoz Centeno, María de la Cruz | es |
dc.creator | Mendoza, Manuel | es |
dc.creator | Simon, Marie-Noelle | es |
dc.creator | Chávez de Diego, Sebastián | es |
dc.creator | Geli, Vincent | es |
dc.date.accessioned | 2018-05-25T08:54:02Z | |
dc.date.available | 2018-05-25T08:54:02Z | |
dc.date.issued | 2018-03-27 | |
dc.identifier.citation | Maya Miles, D., Peñate Salas, X., Sanmartín Olmo, T., Jourquin, F., Muñoz Centeno, M.d.l.C., Mendoza, M.,...,Geli, V. (2018). High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1. Elife, 7, e35337-1-e35337-25. | |
dc.identifier.issn | 2050-084X | es |
dc.identifier.uri | https://hdl.handle.net/11441/75135 | |
dc.description.abstract | Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source of genome instability in cancer. Here, we show in Saccharomyces cerevisiae that abnormal accumulations of histones are sufficient to induce WGDs. Our results link these WGDs to a reduced incorporation of the histone variant H2A.Z to chromatin. Moreover, we show that high levels of histones promote Swe1WEE1 stabilisation thereby triggering the phosphorylation and inhibition of Cdc28CDK1 through a mechanism different of the canonical DNA damage response. Our results link high levels of histones to a specific type of genome instability that is quite frequently observed in cancer and uncovers a new mechanism that might be able to respond to high levels of histones. | es |
dc.description.sponsorship | European Research Council | es |
dc.description.sponsorship | Spanish Ministry of Economy and Competitiveness | es |
dc.description.sponsorship | Centro de Excelencia Severo Ochoa 2013–2017 | es |
dc.description.sponsorship | Spanish MiNECO | es |
dc.description.sponsorship | Regional Andalusian Government | es |
dc.description.sponsorship | European Union funds (FEDER) | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | eLife Sciences | es |
dc.relation.ispartof | Elife, 7, e35337-1-e35337-25. | |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América | * |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Chromosomes | es |
dc.subject | Genes | es |
dc.subject | Histones | es |
dc.title | High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1 | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Instituto de Biomedicina de Sevilla (IBIS) | es |
dc.relation.projectID | European Research Council 2010-St- 20091118 | es |
dc.relation.projectID | Spanish Ministry of Economy and Competitiveness BFU2012-37162 | es |
dc.relation.projectID | Centro de Excelencia Severo Ochoa 2013–2017 SEV-2012–0208 | es |
dc.relation.projectID | Spanish MiNECO BFU2013-48643-C3-1-P | es |
dc.relation.projectID | Regional Andalusian Government P12-BIO1938MO | es |
dc.relation.projectID | European Union funds (FEDER) BFU2013-48643-C3-1-P P12-BIO1938MO | es |
dc.relation.publisherversion | https://doi.org/10.7554/eLife.35337 | es |
dc.identifier.doi | 10.7554/eLife.35337 | es |
idus.format.extent | 25 p. | es |
dc.journaltitle | Elife | es |
dc.publication.volumen | 7 | es |
dc.publication.initialPage | e35337-1 | es |
dc.publication.endPage | e35337-25 | es |