dc.creator | Elena-Real, Carlos A. | es |
dc.creator | Díaz Quintana, Antonio Jesús | es |
dc.creator | González Arzola, Katiuska | es |
dc.creator | Velázquez Campoy, Adrián | es |
dc.creator | Orzáez, Mar | es |
dc.creator | López Rivas, Abelardo | es |
dc.creator | Gil Caballero, Sergio | es |
dc.creator | Rosa Acosta, Miguel Ángel de la | es |
dc.creator | Díaz Moreno, Irene | es |
dc.date.accessioned | 2018-03-23T11:32:54Z | |
dc.date.available | 2018-03-23T11:32:54Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Elena-Real, C.A., Díaz Quintana, A.J., González Arzola, K., Velázquez Campoy, A., Orzáez, M., López Rivas, A.,...,Díaz Moreno, I. (2018). Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition. Cell Death and Disease, 9(3), 365. | |
dc.identifier.issn | 2041-4889 | es |
dc.identifier.uri | https://hdl.handle.net/11441/71306 | |
dc.description.abstract | Apoptosis is a highly regulated form of programmed cell death, essential to the development and homeostasis of multicellular organisms. Cytochrome c is a central figure in the activation of the apoptotic intrinsic pathway, thereby activating the caspase cascade through its interaction with Apaf-1. Our recent studies have revealed 14-3-3ε (a direct inhibitor of Apaf-1) as a cytosolic cytochrome c target. Here we explore the cytochrome c / 14-3-3ε interaction and show the ability of cytochrome c to block 14-3-3ε-mediated Apaf-1 inhibition, thereby unveiling a novel function for cytochrome c as an indirect activator of caspase-9/3. We have used calorimetry, NMR spectroscopy, site mutagenesis and computational calculations to provide an insight into the structural features of the cytochrome c / 14-3-3ε complex. Overall, these findings suggest an additional cytochrome c-mediated mechanism to modulate apoptosome formation, shedding light onto the rigorous apoptotic regulation network | es |
dc.description.sponsorship | España Ministerio de Economía, Industria y Competitividad BFU2015-71017/BMC, SAF2015-64383-P and BFU2013- 47064P/BMC | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Nature Publishing Group | es |
dc.relation.ispartof | Cell Death and Disease, 9(3), 365. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular | es |
dc.relation.projectID | BFU2015-71017/BMC | es |
dc.relation.projectID | SAF2015-64383-P | es |
dc.relation.projectID | BFU2013- 47064P/BMC | es |
dc.relation.publisherversion | http://dx.doi.org/10.1038/s41419-018-0408-1 | es |
dc.identifier.doi | 10.1038/s41419-018-0408-1 | es |
idus.format.extent | 13 p. | es |
dc.journaltitle | Cell Death and Disease | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | | es |
dc.publication.initialPage | 365 | es |
dc.publication.endPage | | es |
dc.contributor.funder | Ministerio de Economia, Industria y Competitividad (MINECO). España | |