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dc.creatorRodríguez Luna, Azahara Maríaes
dc.creatorTalero Barrientos, Elena Mªes
dc.creatorTerencio, María del Carmenes
dc.creatorGonzález Rodríguez, María Luisaes
dc.creatorRabasco Álvarez, Antonio Maríaes
dc.creatorReyes, Carolina de loses
dc.creatorMotilva Sánchez, Virginiaes
dc.creatorÁvila Román, Francisco Javieres
dc.date.accessioned2018-01-12T14:45:14Z
dc.date.available2018-01-12T14:45:14Z
dc.date.issued2018
dc.identifier.citationRodríguez Luna, A.M., Talero Barrientos, E.M., Terencio, M.d.C., González Rodríguez, M.L., Rabasco Álvarez, A.M., Reyes, C.d.l.,...,Ávila Román, J. (2018). Topical Application of Glycolipids from Isochrysis galbana Prevents Epidermal Hyperplasia in Mice. Marine Drugs, 16 (1), 2-.
dc.identifier.issn1660-3397es
dc.identifier.urihttp://hdl.handle.net/11441/68946
dc.description.abstractChronic inflammatory skin diseases such as psoriasis have a significant impact on society. Currently, the major topical treatments have many side effects, making their continued use in patients difficult. Microalgae have emerged as a source of bio-active molecules such as glycolipids with potent anti-inflammatory properties. We aimed to investigate the effects of a glycolipid (MGMG-A) and a glycolipid fraction (MGDG) obtained from the microalga Isochrysis galbana on a TPA-induced epidermal hyperplasia murine model. In a first set of experiments, we examined the preventive effects of MGMG-A and MGDG dissolved in acetone on TPA-induced hyperplasia model in mice. In a second step, we performed an in vivo permeability study by using rhodamine-containing cream, ointment, or gel to determinate the formulation that preserves the skin architecture and reaches deeper. The selected formulation was assayed to ensure the stability and enhanced permeation properties of the samples in an ex vivo experiment. Finally, MGDG-containing cream was assessed in the hyperplasia murine model. The results showed that pre-treatment with acetone-dissolved glycolipids reduced skin edema, epidermal thickness, and pro-inflammatory cytokine production (TNF-α, IL-1β, IL-6, IL-17) in epidermal tissue. The in vivo and ex vivo permeation studies showed that the cream formulation had the best permeability profile. In the same way, MGDG-cream formulation showed better permeation than acetone-dissolved preparation. MGDG-cream application attenuated TPA-induced skin edema, improved histopathological features, and showed a reduction of the inflammatory cell infiltrate. In addition, this formulation inhibited epidermal expression of COX-2 in a similar way to dexamethasone. Our results suggest that an MGDG-containing cream could be an emerging therapeutic strategy for the treatment of inflammatory skin pathologies such as psoriasis.es
dc.description.sponsorshipMinisterio de Economía y Competitividad IPT-2012-1370-060000es
dc.description.sponsorshipJunta de Andalucía P12-AGR-430es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es
dc.relation.ispartofMarine Drugs, 16 (1), 2-.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGlycolipidses
dc.subjectMGDGes
dc.subjectSkines
dc.subjectInflammationes
dc.subjectEpidermal hyperplasiaes
dc.subjectMicroalgaees
dc.subjectIsochrysis galbanaes
dc.titleTopical Application of Glycolipids from Isochrysis galbana Prevents Epidermal Hyperplasia in Micees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéuticaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacologíaes
dc.relation.projectIDIPT-2012-1370-060000es
dc.relation.projectIDP12-AGR-430es
dc.relation.publisherversionhttp://dx.doi.org/10.3390/md16010002es
dc.identifier.doi10.3390/md16010002es
idus.format.extent19 p.es
dc.journaltitleMarine Drugses
dc.publication.volumen16es
dc.publication.issue1es
dc.publication.initialPage2es
dc.contributor.funderMinisterio de Economía y Competitividad (MINECO). España
dc.contributor.funderJunta de Andalucía

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