Artículo
Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic
Autor/es | Rojo Marcos, Francisco Javier
Viana, Renato Ribeiro Bonechi, Elena Richichi, Barbara Ballerini, Clara Nativi, Cristina Comito, Giuseppina |
Fecha de publicación | 2014-06-10 |
Fecha de depósito | 2017-08-21 |
Publicado en |
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Resumen | Vaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response. Here, we describe ... Vaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response. Here, we describe the convergent synthesis of the bifunctional multivalent glycodendron 5, which contains nine residues of mannose for DC targeting and one residue of an immunogenic mimetic of a carbohydrate melanoma associated antigen. The immunological assays demonstrated that the glycodendron 5 is able to induce human immature DC activation in terms of a phenotype expression of co-stimulatory molecules expression and MHCII. Furthermore, DCs activated by the glycodendron 5 stimulate T lymphocytes to proliferate in a mixed lymphocytes reaction (MLR). |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España |
Identificador del proyecto | info:eu-repo/grantAgreement/MINECO/CTQ2011-23410
213592 |
Cita | Rojo Marcos, F.J., Viana, R.R., Bonechi, E., Richichi, B., Ballerini, C., Nativi, C. y Comito, G. (2014). Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic. Beilstein Journal of Organic Chemistry, 10, 1317-1324. |
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