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Vasoactive intestinal peptide induces cell cycle arrest and regulatory functions in human T cells at multiple levels
dc.creator | Anderson, Per | es |
dc.creator | Gonzalez-Rey, Elena | es |
dc.date.accessioned | 2017-06-19T10:32:10Z | |
dc.date.available | 2017-06-19T10:32:10Z | |
dc.date.issued | 2010-05 | |
dc.identifier.citation | Anderson, P. y Gonzalez-Rey, E. (2010). Vasoactive intestinal peptide induces cell cycle arrest and regulatory functions in human T cells at multiple levels. Molecular and Cellular Biology, 30 (10), 2537-2551. | |
dc.identifier.issn | 02707306 | es |
dc.identifier.uri | http://hdl.handle.net/11441/61339 | |
dc.description.abstract | Vasoactive intestinal peptide (VIP) is a potent anti-inflammatory neuropeptide that, by inhibiting Th1-driven responses and inducing the emergence of regulatory T cells (Treg), has been proven successful in the induction of tolerance in various experimental models of autoimmune disorders. Here, we investigate the molecular mechanisms involved in VIP-induced tolerance. VIP treatment in the presence of T-cell receptor (TCR) signaling and CD28 costimulation induced cell cycle arrest in human T cells. VIP blocked G1/S transition and inhibited the synthesis of cyclins D3 and E and the activation of the cyclin-dependent kinases (CDKs) cdk2 and cdk4. This effect was accompanied by maintenance of threshold levels of the CDK inhibitor p27kip1 and impairment of phosphatidylinositol 3-kinase (PI3K)-Akt signaling. Inhibition of interleukin 2 (IL-2) transcription and downregulation of signaling through NFAT, AP-1, and Ras-Raf paralleled the VIPinduced cell cycle arrest. Noteworthy from a functional point of view is the fact that VIP-treated T cells show a regulatory phenotype characterized by high expression of CD25, cytotoxic-T-lymphocyte-associated protein 4 (CTLA4), and Forkhead box protein 3 (FoxP3) and potent suppressive activities against effector T cells. CTLA4 appears to be critically involved in the generation and suppressive activities of VIP-induced Treg. Finally, cyclic AMP (cAMP) and protein kinase A (PKA) activation seems to mediate the VIP-induced cell cycle arrest and Treg generation. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | American Society for Microbiology | es |
dc.relation.ispartof | Molecular and Cellular Biology, 30 (10), 2537-2551. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Vasoactive intestinal peptide induces cell cycle arrest and regulatory functions in human T cells at multiple levels | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.identifier.doi | 10.1128/MCB.01282-09 | es |
dc.contributor.group | Universidad de Sevilla.Bioquímica Médica y Biología Molecular e Inmunología | es |
idus.format.extent | 15 | es |
dc.journaltitle | Molecular and Cellular Biology | es |
dc.publication.volumen | 30 | es |
dc.publication.issue | 10 | es |
dc.publication.initialPage | 2537 | es |
dc.publication.endPage | 2551 | es |
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