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dc.creatorVázquez Marrufo, Manueles
dc.creatorGalvao Carmona, Alejandroes
dc.creatorGonzález Rosa, Javieres
dc.creatorHidalgo Muñoz, Antonio Rafaeles
dc.creatorBorges, Mónicaes
dc.creatorRuiz Peña, Juan L.es
dc.creatorIzquierdo Ayuso, Guillermoes
dc.date.accessioned2017-06-06T07:17:50Z
dc.date.available2017-06-06T07:17:50Z
dc.date.issued2014
dc.identifier.citationVázquez Marrufo, M., Galvao Carmona, A., González Rosa, J., Hidalgo Muñoz, A.R., Borges, M., Ruiz Peña, J.L. y Izquierdo Ayuso, G. (2014). Neural correlates of alerting and orienting impairment in multiple sclerosis patients. PLOS One, 9 (5)
dc.identifier.issn1932-6203es
dc.identifier.urihttp://hdl.handle.net/11441/60971
dc.description.abstractBackground A considerable percentage of multiple sclerosis patients have attentional impairment, but understanding its neurophysiological basis remains a challenge. The Attention Network Test allows 3 attentional networks to be studied. Previous behavioural studies using this test have shown that the alerting network is impaired in multiple sclerosis. The aim of this study was to identify neurophysiological indexes of the attention impairment in relapsing-remitting multiple sclerosis patients using this test. Results After general slowing had been removed in patients group to isolate the effects of each condition, some behavioral differences between them were obtained. About Contingent Negative Variation, a statistically significant decrement were found in the amplitude for Central and Spatial Cue Conditions for patient group (p<0.05). ANOVAs showed for the patient group a significant latency delay for P1 and N1 components (p<0.05) and a decrease of P3 amplitude for congruent and incongruent stimuli (p<0.01). With regard to correlation analysis, PASAT-3s and SDMT showed significant correlations with behavioral measures of the Attention Network Test (p<0.01) and an ERP parameter (CNV amplitude). Conclusions Behavioral data are highly correlated with the neuropsychological scores and show that the alerting and orienting mechanisms in the patient group were impaired. Reduced amplitude for the Contingent Negative Variation in the patient group suggests that this component could be a physiological marker related to the alerting and orienting impairment in relapsing-remitting multiple sclerosis. P1 and N1 delayed latencies are evidence of the demyelination process that causes impairment in the first steps of the visual sensory processing. Lastly, P3 amplitude shows a general decrease for the pathological group probably indexing a more central impairment. These results suggest that the Attention Network Test give evidence of multiple levels of attention impairment, which could help in the assessment and treatment of relapsing-remitting multiple sclerosis patients.es
dc.description.sponsorshipMinisterio de Economía y Competitividad de España PSI2010-16825es
dc.description.sponsorshipAsociación Neuroinvestes
dc.description.sponsorshipAsociación Sanitaria Virgen Macarenaes
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherPublic Library of Sciencees
dc.relation.ispartofPLOS One, 9 (5)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleNeural correlates of alerting and orienting impairment in multiple sclerosis patientses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Psicología Experimentales
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PSI2010-16825es
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0097226es
dc.identifier.doi10.1371/journal.pone.0097226es
idus.format.extent13 p.es
dc.journaltitlePLOS Onees
dc.publication.volumen9es
dc.publication.issue5es

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